HCSGD entry for TPPP
1. General information
| Official gene symbol | TPPP |
|---|---|
| Entrez ID | 11076 |
| Gene full name | tubulin polymerization promoting protein |
| Other gene symbols | TPPP/p25 TPPP1 p24 p25 p25alpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001578 | Microtubule bundle formation | IDA ISS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0008017 | Microtubule binding | ISS | molecular_function |
| GO:0015631 | Tubulin binding | IDA ISS | molecular_function |
| GO:0031334 | Positive regulation of protein complex assembly | ISS | biological_process |
| GO:0032273 | Positive regulation of protein polymerization | IDA | biological_process |
| GO:0046785 | Microtubule polymerization | IDA ISS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4793076137 | 0.9062078568 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0691063259 |
| GSE13712_SHEAR | Down | -0.1791919311 |
| GSE13712_STATIC | Up | 0.0641666301 |
| GSE19018 | Up | 0.0585412220 |
| GSE19899_A1 | Up | 0.0179872204 |
| GSE19899_A2 | Up | 0.1055281373 |
| PubMed_21979375_A1 | Up | 0.1216408815 |
| PubMed_21979375_A2 | Down | -0.0932013717 |
| GSE35957 | Up | 0.1165095270 |
| GSE36640 | Down | -0.1277761526 |
| GSE54402 | Up | 0.2113676212 |
| GSE9593 | Up | 0.0521789596 |
| GSE43922 | Up | 0.0645689981 |
| GSE24585 | Up | 0.3529632572 |
| GSE37065 | Up | 0.0420801044 |
| GSE28863_A1 | Down | -0.2046815105 |
| GSE28863_A2 | Down | -0.0841222953 |
| GSE28863_A3 | Up | 0.2889855954 |
| GSE28863_A4 | Up | 0.1119283645 |
| GSE48662 | Down | -0.0260513553 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025429 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029260 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
