HCSGD entry for CHD2
1. General information
| Official gene symbol | CHD2 |
|---|---|
| Entrez ID | 1106 |
| Gene full name | chromodomain helicase DNA binding protein 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001046 | Core promoter sequence-specific DNA binding | ISS | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA TAS | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | molecular_function |
| GO:0004386 | Helicase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0007517 | Muscle organ development | ISS | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0032508 | DNA duplex unwinding | TAS | biological_process |
| GO:0042393 | Histone binding | ISS | molecular_function |
| GO:0060218 | Hematopoietic stem cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8028663919 | 0.1114044793 | 0.9999902473 | 0.6394347864 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1298610560 |
| GSE13712_SHEAR | Up | 0.5729521450 |
| GSE13712_STATIC | Up | 0.0477042070 |
| GSE19018 | Down | -0.1736345207 |
| GSE19899_A1 | Down | -0.3048680421 |
| GSE19899_A2 | Down | -0.7618525708 |
| PubMed_21979375_A1 | Down | -0.6706141208 |
| PubMed_21979375_A2 | Down | -0.7083816332 |
| GSE35957 | Down | -0.2669879119 |
| GSE36640 | Down | -0.0920578281 |
| GSE54402 | Down | -0.0163847820 |
| GSE9593 | Down | -0.2864295080 |
| GSE43922 | Down | -0.4380123701 |
| GSE24585 | Up | 0.6714158100 |
| GSE37065 | Up | 0.3015051938 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1135950580 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-450a-5p | MIMAT0001545 | MIRT042397 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042664 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-5p | MIMAT0000731 | MIRT043970 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
