HCSGD entry for WWP1

1. General information

Official gene symbolWWP1
Entrez ID11059
Gene full nameWW domain containing E3 ubiquitin protein ligase 1
Other gene symbolsAIP5 Tiul1 hSDRP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexNAScellular_component
GO:0004842Ubiquitin-protein ligase activityIBA IEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIBAcellular_component
GO:0005737CytoplasmIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007417Central nervous system developmentNASbiological_process
GO:0016567Protein ubiquitinationTASbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIBAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIEA ISSbiological_process
GO:0046718Viral entry into host cellTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27150029630.53930173250.96849318521.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0528755596
GSE13712_SHEARUp0.7468836224
GSE13712_STATICUp0.6930447506
GSE19018Down-0.0482101414
GSE19899_A1Up0.3820517876
GSE19899_A2Up0.1711033218
PubMed_21979375_A1Down-0.1092699789
PubMed_21979375_A2Up0.0148811497
GSE35957Up0.0089357102
GSE36640Up0.0483373303
GSE54402Up0.0312220831
GSE9593Up0.0039359009
GSE43922Down-0.0244450783
GSE24585Down-0.7136220387
GSE37065Up0.0183338608
GSE28863_A1Down-0.0616130597
GSE28863_A2Up0.1223168272
GSE28863_A3Up0.1347253557
GSE28863_A4Down-0.0823210087
GSE48662Down-0.2326194242

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21795702WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) plays an important role in the proliferation of tumor cells and the lifespan of Caenorhabditis elegans
21795702Here, we show that the expression patterns of p27(Kip1) and WWP1 are inversely correlated during cellular senescence
21795702Moreover, the overexpression of WWP1 delayed senescence, whereas the knockdown of WWP1 led to premature senescence in human fibroblasts
21795702Furthermore, we demonstrate that WWP1 repressed endogenous p27(Kip1) expression through ubiquitin-proteasome-mediated degradation
21795702Additionally, WWP1 had a strong preference for catalyzing the Lys-48-linked polyubiquitination of p27(Kip1) in vitro
21795702Finally, we demonstrate that WWP1 markedly inhibited the replicative senescence induced by p27(Kip1) by promoting p27(Kip1) degradation
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