HCSGD entry for PIM2
1. General information
| Official gene symbol | PIM2 |
|---|---|
| Entrez ID | 11040 |
| Gene full name | pim-2 oncogene |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006468 | Protein phosphorylation | IDA ISS | biological_process |
| GO:0007140 | Male meiosis | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0008637 | Apoptotic mitochondrial changes | IEA | biological_process |
| GO:0009615 | Response to virus | IEP | biological_process |
| GO:0010508 | Positive regulation of autophagy | ISS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA IEA | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | ISS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0050821 | Protein stabilization | IMP ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0262049732 | 0.9465094867 | 0.3783549643 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1829328810 |
| GSE13712_SHEAR | Down | -0.1155687169 |
| GSE13712_STATIC | Up | 0.1852110064 |
| GSE19018 | Up | 0.5248683876 |
| GSE19899_A1 | Up | 0.3299317100 |
| GSE19899_A2 | Up | 0.8945907076 |
| PubMed_21979375_A1 | Up | 0.4022160965 |
| PubMed_21979375_A2 | Up | 0.4515928725 |
| GSE35957 | Down | -0.0122258850 |
| GSE36640 | Down | -0.0419025361 |
| GSE54402 | Up | 1.5391629104 |
| GSE9593 | Down | -0.1646147498 |
| GSE43922 | Up | 0.3323874596 |
| GSE24585 | Down | -0.1270711360 |
| GSE37065 | Up | 0.2121987209 |
| GSE28863_A1 | Down | -0.3922173095 |
| GSE28863_A2 | Down | -0.1272492775 |
| GSE28863_A3 | Up | 0.1618431881 |
| GSE28863_A4 | Up | 0.1906491064 |
| GSE48662 | Down | -0.0784700894 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030307 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030617 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036440 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26091153 | 98-fold); PIM-2 oncogene, a positive regulator of autophagy (3-fold); WIPI49 (linked to starvation-induced autophagy) (upregulated 2 |
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