HCSGD entry for RCC1
1. General information
| Official gene symbol | RCC1 |
|---|---|
| Entrez ID | 1104 |
| Gene full name | regulator of chromosome condensation 1 |
| Other gene symbols | CHC1 RCC1-I SNHG3-RCC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | biological_process |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0000794 | Condensed nuclear chromosome | IDA | cellular_component |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0005087 | Ran guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0007052 | Mitotic spindle organization | IDA | biological_process |
| GO:0007059 | Chromosome segregation | IMP | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007088 | Regulation of mitosis | IDA | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0031492 | Nucleosomal DNA binding | IDA | molecular_function |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0032316 | Regulation of Ran GTPase activity | IDA | biological_process |
| GO:0032318 | Regulation of Ras GTPase activity | IDA | biological_process |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0043087 | Regulation of GTPase activity | IDA | biological_process |
| GO:0051225 | Spindle assembly | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9483479351 | 0.0310968390 | 0.9999902473 | 0.3313753331 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0032530733 |
| GSE13712_SHEAR | Down | -0.2844455847 |
| GSE13712_STATIC | Down | -0.0167251283 |
| GSE19018 | Down | -0.0669526939 |
| GSE19899_A1 | Down | -0.2671741901 |
| GSE19899_A2 | Down | -0.4124049464 |
| PubMed_21979375_A1 | Down | -0.2369028356 |
| PubMed_21979375_A2 | Down | -0.8541303166 |
| GSE35957 | Down | -0.0387224164 |
| GSE36640 | Down | -1.9188024554 |
| GSE54402 | Down | -0.0502395560 |
| GSE9593 | Down | -0.4808877143 |
| GSE43922 | Up | 0.1849862619 |
| GSE24585 | Down | -0.3793467545 |
| GSE37065 | Down | -0.2829645249 |
| GSE28863_A1 | Down | -0.0968504073 |
| GSE28863_A2 | Up | 0.4514416599 |
| GSE28863_A3 | Down | -0.0489587874 |
| GSE28863_A4 | Down | -0.1559312852 |
| GSE48662 | Down | -0.0048012800 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016531 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016531 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023213 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-941 | MIMAT0004984 | MIRT036582 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040885 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045518 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049090 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26864624 | However, the role of RCC1 or RanGTP in promoting cell proliferation or DDR is not clear |
| 26864624 | We show that RCC1 overexpression in normal cells increased cellular RanGTP levels and accelerated the cell cycle and DNA damage repair |
| 26864624 | As a result, normal cells overexpressing RCC1 evaded DNA damage-induced cell cycle arrest and senescence, mimicking colorectal carcinoma cells with high endogenous RCC1 levels |
| 26864624 | Through the essential role of RCC1 in regulation of cellular RanGTP levels and NCT, RCC1 expression enables the proliferation of cells that sustain DNA damage |
| 10491433 | METHODS: YACs specific for human chromosome region 3p14 were transduced by spheroplast fusion into cells of the human nonpapillary renal carcinoma cell line RCC-1, which shows a cytogenetically detectable 3p deletion and is tumorigenic in nude mice |
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