HCSGD entry for RAB31
1. General information
| Official gene symbol | RAB31 |
|---|---|
| Entrez ID | 11031 |
| Gene full name | RAB31, member RAS oncogene family |
| Other gene symbols | Rab22B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0005525 | GTP binding | IDA IEA | molecular_function |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0030670 | Phagocytic vesicle membrane | IEA | cellular_component |
| GO:0031623 | Receptor internalization | IMP | biological_process |
| GO:0032588 | Trans-Golgi network membrane | IDA | cellular_component |
| GO:0032869 | Cellular response to insulin stimulus | IMP | biological_process |
| GO:0043001 | Golgi to plasma membrane protein transport | IMP | biological_process |
| GO:0045055 | Regulated secretory pathway | IMP | biological_process |
| GO:0045335 | Phagocytic vesicle | IDA | cellular_component |
| GO:0090382 | Phagosome maturation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0078805327 | 0.1960760685 | 0.2297785398 | 0.8576268982 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8253137206 |
| GSE13712_SHEAR | Down | -0.5196831395 |
| GSE13712_STATIC | Down | -0.3570327543 |
| GSE19018 | Down | -0.4152913150 |
| GSE19899_A1 | Up | 1.2753958261 |
| GSE19899_A2 | Up | 1.7078593268 |
| PubMed_21979375_A1 | Up | 1.1249526853 |
| PubMed_21979375_A2 | Up | 1.8450478766 |
| GSE35957 | Down | -0.2910612319 |
| GSE36640 | Down | -0.9665397546 |
| GSE54402 | Up | 1.5345445985 |
| GSE9593 | Down | -0.4350005977 |
| GSE43922 | Up | 0.5035836729 |
| GSE24585 | Down | -1.0177107442 |
| GSE37065 | Up | 0.4947574006 |
| GSE28863_A1 | Up | 0.0625199948 |
| GSE28863_A2 | Up | 0.0183844709 |
| GSE28863_A3 | Up | 0.0050122151 |
| GSE28863_A4 | Up | 0.0683328500 |
| GSE48662 | Down | -0.0865566981 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-140-3p | MIMAT0004597 | MIRT021663 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022839 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026067 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26165933 | Bioinformatics analyses suggested that Rab1a and Rab31, which are associated with cell autophagy, were targeted by both miR-184 and miR-150 |
| 26165933 | Furthermore, dual luciferase reporter assays revealed that miR-184 and miR-150 bound to the 3'-UTR of Rab1a and Rab31 mRNAs |
| 26165933 | Transfection of miR-184 and miR-150 mimics into young GMCs suppressed the expression of Rab1a and Rab31 |
| 26165933 | However, miR-184 and miR-150 inhibitors promoted autophagy and reduced oxidative damage by upregulating Rab1a and Rab31 in old GMCs |
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