HCSGD entry for CHAT
1. General information
| Official gene symbol | CHAT |
|---|---|
| Entrez ID | 1103 |
| Gene full name | choline O-acetyltransferase |
| Other gene symbols | CHOACTASE CMS1A CMS1A2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004102 | Choline O-acetyltransferase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006656 | Phosphatidylcholine biosynthetic process | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007269 | Neurotransmitter secretion | TAS | biological_process |
| GO:0007274 | Neuromuscular synaptic transmission | IEA | biological_process |
| GO:0007517 | Muscle organ development | IEA | biological_process |
| GO:0007529 | Establishment of synaptic specificity at neuromuscular junction | IEA | biological_process |
| GO:0007622 | Rhythmic behavior | IEA | biological_process |
| GO:0007628 | Adult walking behavior | IEA | biological_process |
| GO:0016358 | Dendrite development | IEA | biological_process |
| GO:0016746 | Transferase activity, transferring acyl groups | IEA | molecular_function |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0042136 | Neurotransmitter biosynthetic process | IEA | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043179 | Rhythmic excitation | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2369948064 | 0.9373977584 | 0.9212731207 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0745947760 |
| GSE13712_SHEAR | Up | 0.0184323441 |
| GSE13712_STATIC | Up | 0.0020029800 |
| GSE19018 | Up | 0.0007765413 |
| GSE19899_A1 | Up | 0.1567467234 |
| GSE19899_A2 | Up | 0.0059479385 |
| PubMed_21979375_A1 | Down | -0.1437585854 |
| PubMed_21979375_A2 | Up | 0.1046137704 |
| GSE35957 | Up | 0.1948202441 |
| GSE36640 | Up | 0.1190615656 |
| GSE54402 | Up | 0.0798503648 |
| GSE9593 | Up | 0.1888244334 |
| GSE43922 | Up | 0.0891904359 |
| GSE24585 | Down | -0.0882386145 |
| GSE37065 | Up | 0.0356624173 |
| GSE28863_A1 | Down | -0.0930407774 |
| GSE28863_A2 | Up | 0.0449030451 |
| GSE28863_A3 | Up | 0.1701352521 |
| GSE28863_A4 | Up | 0.0517704471 |
| GSE48662 | Up | 1.3877272088 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Nicotine | DB00184 | APRD00200 | EXPT02315 | DB09463 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017364 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT046123 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
