HCSGD entry for LIAS
1. General information
| Official gene symbol | LIAS |
|---|---|
| Entrez ID | 11019 |
| Gene full name | lipoic acid synthetase |
| Other gene symbols | LAS LIP1 LS PDHLD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0005739 | Mitochondrion | ISS | cellular_component |
| GO:0006954 | Inflammatory response | ISS | biological_process |
| GO:0006979 | Response to oxidative stress | ISS | biological_process |
| GO:0009107 | Lipoate biosynthetic process | ISS | biological_process |
| GO:0016992 | Lipoate synthase activity | IEA ISS | molecular_function |
| GO:0032496 | Response to lipopolysaccharide | ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1739655142 | 0.6198528931 | 0.8191317174 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3695056876 |
| GSE13712_SHEAR | Up | 0.0422342785 |
| GSE13712_STATIC | Up | 0.1232168831 |
| GSE19018 | Up | 0.0941512578 |
| GSE19899_A1 | Up | 0.2585799707 |
| GSE19899_A2 | Up | 0.1712623417 |
| PubMed_21979375_A1 | Up | 0.9817052692 |
| PubMed_21979375_A2 | Up | 0.1420870134 |
| GSE35957 | Down | -0.9630475173 |
| GSE36640 | Down | -0.0366066750 |
| GSE54402 | Down | -0.1310536610 |
| GSE9593 | Down | -0.0503160541 |
| GSE43922 | Up | 0.1722708446 |
| GSE24585 | Up | 0.0574290371 |
| GSE37065 | Up | 0.0664550616 |
| GSE28863_A1 | Up | 0.1117392092 |
| GSE28863_A2 | Up | 0.0970633977 |
| GSE28863_A3 | Down | -0.3564556318 |
| GSE28863_A4 | Down | -0.2099179744 |
| GSE48662 | Up | 0.0173157506 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028840 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
