HCSGD entry for IL24

1. General information

Official gene symbolIL24
Entrez ID11009
Gene full nameinterleukin 24
Other gene symbolsC49A FISP IL10B MDA7 MOB5 ST16
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005125Cytokine activityIEAmolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0030336Negative regulation of cell migrationIEAbiological_process
GO:0033136Serine phosphorylation of STAT3 proteinIEAbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071353Cellular response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00009807380.95978541090.02777526881.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up5.2267814262
GSE13712_SHEARUp0.0757375780
GSE13712_STATICDown-0.0204722865
GSE19018Up0.3218724602
GSE19899_A1Up0.8809663053
GSE19899_A2Up5.6086458697
PubMed_21979375_A1Up5.2543331050
PubMed_21979375_A2Up4.1846551929
GSE35957Down-0.3213126931
GSE36640Down-0.1902440019
GSE54402Up3.9994789564
GSE9593Up0.0811408298
GSE43922Up1.6588730999
GSE24585Up0.0530800669
GSE37065Down-0.1789188511
GSE28863_A1Down-0.3044614111
GSE28863_A2Up0.8723237275
GSE28863_A3Up0.0998691410
GSE28863_A4Up0.0342817746
GSE48662Down-0.0077322822

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-205-5pMIMAT0000266MIRT005563Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20737563
hsa-miR-205-5pMIMAT0000266MIRT005563Luciferase reporter assayFunctional MTI23212344
hsa-miR-203aMIMAT0000264MIRT006858Luciferase reporter assayFunctional MTI22917968
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19802007JAK1/STAT-activating ligands, interleukin 10 (IL10), IL20, IL24, interferon gamma (IFNgamma), IFNbeta and IL6, were also expressed by senescent cells, supporting autocrine/paracrine activation of JAK1/STAT
19650831This characteristic phenotype included persistently activated DNA damage signalling (detected as 53BP1/gammaH2AX(+) foci), enhanced senescence-associated beta-galactosidase activity, expansion of promyelocytic leukaemia nuclear compartments and induced expression of several cytokines (especially interleukins IL-6, IL-8 and IL-24), overall features shared by cells undergoing replicative or premature cellular senescence
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