HCSGD entry for CKAP4
1. General information
| Official gene symbol | CKAP4 |
|---|---|
| Entrez ID | 10970 |
| Gene full name | cytoskeleton-associated protein 4 |
| Other gene symbols | CLIMP-63 ERGIC-63 p63 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005811 | Lipid particle | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8510853083 | 0.0936252422 | 0.9999902473 | 0.5829926662 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1293910918 |
| GSE13712_SHEAR | Up | 0.0721502009 |
| GSE13712_STATIC | Up | 0.2005827715 |
| GSE19018 | Up | 0.4308757155 |
| GSE19899_A1 | Down | -0.5035863897 |
| GSE19899_A2 | Down | -0.1511334353 |
| PubMed_21979375_A1 | Down | -0.9096809514 |
| PubMed_21979375_A2 | Down | -0.5153933894 |
| GSE35957 | Down | -0.3716485486 |
| GSE36640 | Up | 0.4850537019 |
| GSE54402 | Down | -0.3289487489 |
| GSE9593 | Up | 0.0001070218 |
| GSE43922 | Down | -0.1681136243 |
| GSE24585 | Down | -0.3966698790 |
| GSE37065 | Down | -0.0093257140 |
| GSE28863_A1 | Up | 0.0764078747 |
| GSE28863_A2 | Up | 0.0424883053 |
| GSE28863_A3 | Down | -0.3506562005 |
| GSE28863_A4 | Up | 0.1129895088 |
| GSE48662 | Down | -0.1717876178 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT004057 | Microarray//Microarray;Other | Functional MTI (Weak) | 19073608 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT004057 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022457 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024515 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026345 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036501 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036830 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040356 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047962 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17975794 | A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein |
| 17975794 | By mass spectrometric analysis CLIMP-63, a cytoskeleton-linking membrane protein was identified as the major component of the up-regulated protein band |
| 17975794 | Further experiments revealed that OLO, but not ROSC, strongly up-regulates CLIMP-63 in a dose- and time-dependent manner solely in senescent cells |
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