HCSGD entry for PAPOLA
1. General information
| Official gene symbol | PAPOLA |
|---|---|
| Entrez ID | 10914 |
| Gene full name | poly(A) polymerase alpha |
| Other gene symbols | PAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | ISS | molecular_function |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004652 | Polynucleotide adenylyltransferase activity | IBA IEA ISS | molecular_function |
| GO:0005524 | ATP binding | ISS | molecular_function |
| GO:0005634 | Nucleus | IDA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030145 | Manganese ion binding | ISS | molecular_function |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
| GO:0043631 | RNA polyadenylation | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3385728088 | 0.7823710421 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1578575524 |
| GSE13712_SHEAR | Down | -0.0815085730 |
| GSE13712_STATIC | Up | 0.0078984956 |
| GSE19018 | Down | -0.0899088329 |
| GSE19899_A1 | Up | 0.0644319780 |
| GSE19899_A2 | Up | 0.0734298138 |
| PubMed_21979375_A1 | Up | 0.1483128339 |
| PubMed_21979375_A2 | Down | -0.1804350384 |
| GSE35957 | Up | 0.0023792543 |
| GSE36640 | Down | -0.2651673719 |
| GSE54402 | Up | 0.1013216163 |
| GSE9593 | Down | -0.1861251060 |
| GSE43922 | Up | 0.3343156849 |
| GSE24585 | Down | -0.0061772393 |
| GSE37065 | Up | 0.2007017078 |
| GSE28863_A1 | Up | 0.4558059731 |
| GSE28863_A2 | Up | 0.2813049312 |
| GSE28863_A3 | Down | -0.3500885928 |
| GSE28863_A4 | Up | 0.1041293459 |
| GSE48662 | Up | 0.4247065181 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Cordycepin Triphosphate | DB01860 | EXPT00163 |
| 3-Sulfinoalanine | DB02153 | EXPT01032 |
| Triphospate | DB03896 | EXPT00188 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT005093 | Microarray | Functional MTI (Weak) | 19193853 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020257 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028127 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037348 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044470 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052114 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
