HCSGD entry for PNPLA6
1. General information
| Official gene symbol | PNPLA6 |
|---|---|
| Entrez ID | 10908 |
| Gene full name | patatin-like phospholipase domain containing 6 |
| Other gene symbols | NTE NTEMND SPG39 iPLA2delta sws |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0004622 | Lysophospholipase activity | IEA | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0009887 | Organ morphogenesis | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0046470 | Phosphatidylcholine metabolic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0112370997 | 0.9126195395 | 0.2681520399 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5495565585 |
| GSE13712_SHEAR | Down | -0.1597163029 |
| GSE13712_STATIC | Down | -0.0463822616 |
| GSE19018 | Up | 0.2254836908 |
| GSE19899_A1 | Up | 0.0200213221 |
| GSE19899_A2 | Up | 1.3906089294 |
| PubMed_21979375_A1 | Up | 0.9283809260 |
| PubMed_21979375_A2 | Up | 2.9343993184 |
| GSE35957 | Up | 0.0021365769 |
| GSE36640 | Up | 0.6852636585 |
| GSE54402 | Up | 0.1459623895 |
| GSE9593 | Down | -0.0213389239 |
| GSE43922 | Up | 0.3806858074 |
| GSE24585 | Down | -0.1112625029 |
| GSE37065 | Down | -0.2295494608 |
| GSE28863_A1 | Down | -0.0838109244 |
| GSE28863_A2 | Down | -0.2040340261 |
| GSE28863_A3 | Up | 0.3495490765 |
| GSE28863_A4 | Down | -0.0747061225 |
| GSE48662 | Up | 0.4617929792 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT005264 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT005264 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018654 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025538 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027172 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
