HCSGD entry for LYVE1
1. General information
| Official gene symbol | LYVE1 |
|---|---|
| Entrez ID | 10894 |
| Gene full name | lymphatic vessel endothelial hyaluronan receptor 1 |
| Other gene symbols | CRSBP-1 HAR LYVE-1 XLKD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0005540 | Hyaluronic acid binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0007160 | Cell-matrix adhesion | TAS | biological_process |
| GO:0009611 | Response to wounding | TAS | biological_process |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030212 | Hyaluronan metabolic process | TAS | biological_process |
| GO:0030214 | Hyaluronan catabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8437171156 | 0.0683573382 | 0.9999902473 | 0.4934814866 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0143364011 |
| GSE13712_SHEAR | Down | -2.5302804748 |
| GSE13712_STATIC | Down | -2.8812191579 |
| GSE19018 | Up | 0.0339065767 |
| GSE19899_A1 | Down | -0.0213536835 |
| GSE19899_A2 | Up | 0.0157402764 |
| PubMed_21979375_A1 | Up | 0.0255153859 |
| PubMed_21979375_A2 | Down | -0.1920045490 |
| GSE35957 | Up | 0.0749198208 |
| GSE36640 | Up | 0.0763263508 |
| GSE54402 | Up | 0.0881245158 |
| GSE9593 | Up | 0.1453005998 |
| GSE43922 | Up | 0.0459862535 |
| GSE24585 | Down | -0.0352758547 |
| GSE37065 | Up | 0.1640466709 |
| GSE28863_A1 | Down | -0.0490865956 |
| GSE28863_A2 | Up | 0.0080354307 |
| GSE28863_A3 | Down | -0.0297452044 |
| GSE28863_A4 | Up | 0.1642869959 |
| GSE48662 | Down | -0.0714451299 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023074 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18355322 | In addition, lymphatic vessel endothelial hyaluronan receptor-1 (Lyve-1) expression in liver sinusoidal endothelial cells in vivo was retained in vitro, suggesting that an organ-specific endothelial characteristic was maintained |
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