HCSGD entry for MALT1

1. General information

Official gene symbolMALT1
Entrez ID10892
Gene full namemucosa associated lymphoid tissue lymphoma translocation gene 1
Other gene symbolsMLT MLT1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001923B-1 B cell differentiationIEAbiological_process
GO:0002020Protease bindingIEAmolecular_function
GO:0002237Response to molecule of bacterial originIEAbiological_process
GO:0002726Positive regulation of T cell cytokine productionIMPbiological_process
GO:0004197Cysteine-type endopeptidase activityNASmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006508ProteolysisIDAbiological_process
GO:0006952Defense responseNASbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityIMPbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0009620Response to fungusIEAbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0019209Kinase activator activityIMPmolecular_function
GO:0031398Positive regulation of protein ubiquitinationNASbiological_process
GO:0032449CBM complexNAScellular_component
GO:0032743Positive regulation of interleukin-2 productionIMPbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042981Regulation of apoptotic processIDAbiological_process
GO:0043066Negative regulation of apoptotic processNASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043621Protein self-associationIPImolecular_function
GO:0045087Innate immune responseIEA TASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050852T cell receptor signaling pathwayIDA TASbiological_process
GO:0050856Regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0050870Positive regulation of T cell activationIC IEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEA IMPbiological_process
GO:0051168Nuclear exportIDAbiological_process
GO:0051259Protein oligomerizationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12971651530.30454274530.73126331121.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5290111443
GSE13712_SHEARUp0.2949197216
GSE13712_STATICUp0.4691690880
GSE19018Up0.1422184892
GSE19899_A1Up0.0203831760
GSE19899_A2Up0.1731501828
PubMed_21979375_A1Up0.9705545086
PubMed_21979375_A2Up0.7532152582
GSE35957Up0.5401967405
GSE36640Down-0.0299774423
GSE54402Up0.6160848232
GSE9593Up0.0999709392
GSE43922Up0.0854753270
GSE24585Down-0.2685952619
GSE37065Down-0.3318130503
GSE28863_A1Down-0.3107244548
GSE28863_A2Up0.0205971765
GSE28863_A3Down-0.2482885194
GSE28863_A4Down-0.0549174411
GSE48662Down-0.3876752982

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030793MicroarrayFunctional MTI (Weak)18591254
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22658522Bcl10 autophagy was highly selective, as shown by the fact that it spared Malt1, a direct Bcl10 binding partner
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