HCSGD entry for GPR83
1. General information
| Official gene symbol | GPR83 |
|---|---|
| Entrez ID | 10888 |
| Gene full name | G protein-coupled receptor 83 |
| Other gene symbols | GIR GPR72 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA TAS | molecular_function |
| GO:0004983 | Neuropeptide Y receptor activity | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2794404126 | 0.8816039132 | 0.9762610964 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2082635410 |
| GSE13712_SHEAR | Down | -0.0821631531 |
| GSE13712_STATIC | Up | 0.0355280088 |
| GSE19018 | Up | 0.3271312280 |
| GSE19899_A1 | Down | -0.0527473300 |
| GSE19899_A2 | Down | -0.0350362438 |
| PubMed_21979375_A1 | Up | 0.1126663064 |
| PubMed_21979375_A2 | Up | 0.1311922779 |
| GSE35957 | Down | -0.1771604211 |
| GSE36640 | Down | -0.0204575284 |
| GSE54402 | Up | 0.1645734317 |
| GSE9593 | Up | 0.2176105481 |
| GSE43922 | Up | 0.0163578989 |
| GSE24585 | Up | 0.0805449737 |
| GSE37065 | Up | 0.0540218882 |
| GSE28863_A1 | Down | -0.2354493496 |
| GSE28863_A2 | Down | -0.0774683676 |
| GSE28863_A3 | Up | 0.1593486002 |
| GSE28863_A4 | Up | 0.1496055518 |
| GSE48662 | Up | 0.9360503005 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT021958 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1 | MIMAT0000416 | MIRT023638 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025093 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26895377 | To identify senescence-associated miRNAs, we performed microarray analyses using wild-type and p53-deficient HCT116 colon carcinoma cells that following gamma-irradiation (gammaIR) are driven into senescence and apoptosis, respectively |
| 26895377 | Overexpression of miR-30e in HCT116 cells not only inhibited gammaIR-, etoposide- or miR-34a-induced caspase-3-like DEVDase activities and cell death, but greatly accelerated and augmented their senescent phenotype |
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