HCSGD entry for SMR3B
1. General information
| Official gene symbol | SMR3B |
|---|---|
| Entrez ID | 10879 |
| Gene full name | submaxillary gland androgen regulated protein 3B |
| Other gene symbols | P-B PBII PRL3 PROL3 SMR1B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0008150 | Biological_process | ND | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5738065271 | 0.6701275104 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | 0.0000000000 |
| GSE13712_SHEAR | Down | -0.3365904663 |
| GSE13712_STATIC | Down | -0.2552048649 |
| GSE19018 | Up | 0.1582646703 |
| GSE19899_A1 | Up | 0.1743201791 |
| GSE19899_A2 | Up | 0.0431908128 |
| PubMed_21979375_A1 | Up | 0.1708302367 |
| PubMed_21979375_A2 | Up | 0.2845651704 |
| GSE35957 | Up | 0.3746907373 |
| GSE36640 | Up | 0.0264407772 |
| GSE54402 | Up | 0.0452128408 |
| GSE9593 | Down | -0.0193564882 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.1471489014 |
| GSE28863_A2 | Down | -0.1598452701 |
| GSE28863_A3 | Down | -0.0944365708 |
| GSE28863_A4 | Up | 0.0232657740 |
| GSE48662 | Up | 0.0139163379 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15236767 | Heavy metals like CrVI, CdII, PbII and SnII have many applications in industry |
| 15236767 | Similar treatments with three additional labour pollutants resulted in the induction of premature senescence by CdII, but not by SnII or PbII |
| 7779576 | Al(III) and Pb(II) salts (300 microM) produce a considerable decrease in cell survival after an exposure period of 4d, evident with the three fetal calf serum concentrations in the culture media: 2, 5, and 10% |
| 7779576 | Taking into account in vitro cell aging, the cytotoxic effects of Al(III) and Pb(II) are greater in senescent fibroblasts than in young cells |
| 7779576 | A mechanism that contributes to cellular toxicity is membrane lipid peroxidation; our results demonstrate that Al(III) and Pb(II) ions, 400 microM, exert an antioxidant-like effect or a pro-oxidant action on cell membranes depending on exposure time |
| 7779576 | We describe significant increases in TBARS formation associated with the presence of 400 microM Al(III) or Pb(II) salts in the culture media |
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