HCSGD entry for PDE10A

1. General information

Official gene symbolPDE10A
Entrez ID10846
Gene full namephosphodiesterase 10A
Other gene symbolsHSPDE10A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityTASmolecular_function
GO:0004118CGMP-stimulated cyclic-nucleotide phosphodiesterase activityIDAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006198CAMP catabolic processIEAbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0010738Regulation of protein kinase A signalingIEAbiological_process
GO:0030552CAMP bindingIDA NASmolecular_function
GO:0030553CGMP bindingNASmolecular_function
GO:0043949Regulation of cAMP-mediated signalingIEAbiological_process
GO:0046069CGMP catabolic processIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:00475553',5'-cyclic-GMP phosphodiesterase activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65266414270.01074935220.99999024730.2053219884

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4045488966
GSE13712_SHEARUp0.5677974042
GSE13712_STATICUp0.9372407623
GSE19018Up0.6697830740
GSE19899_A1Down-0.4051919665
GSE19899_A2Down-1.1213314153
PubMed_21979375_A1Down-0.9971879491
PubMed_21979375_A2Down-1.5032076467
GSE35957Down-0.2701954562
GSE36640Up0.7116869495
GSE54402Down-0.8678789531
GSE9593Up0.0457941419
GSE43922Down-1.0651943032
GSE24585Down-0.7160564674
GSE37065Down-0.1770789252
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0339144821

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DipyridamoleDB00975 APRD00360
PapaverineDB01113 APRD00628 | DB07725
4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazoleDB08383 -
2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinolineDB08384 -
2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinolineDB08386 -
2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinolineDB08387 -
6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINEDB08389 -
6,7-DIMETHOXY-4-[(3R)-3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINEDB08391 -
TofisopamDB08811 -
TriflusalDB08814 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.