HCSGD entry for FRS2

1. General information

Official gene symbolFRS2
Entrez ID10818
Gene full namefibroblast growth factor receptor substrate 2
Other gene symbolsFRS2A FRS2alpha SNT SNT-1 SNT1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityTASbiological_process
GO:0000187Activation of MAPK activityIEAbiological_process
GO:0001702Gastrulation with mouth forming secondIEAbiological_process
GO:0001759Organ inductionIEAbiological_process
GO:0003281Ventricular septum developmentIEAbiological_process
GO:0005068Transmembrane receptor protein tyrosine kinase adaptor activityIEA TASmolecular_function
GO:0005104Fibroblast growth factor receptor bindingIPImolecular_function
GO:0005158Insulin receptor bindingIEAmolecular_function
GO:0005168Neurotrophin TRKA receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005768EndosomeTAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007185Transmembrane receptor protein tyrosine phosphatase signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007405Neuroblast proliferationIEAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIEA IGI TASbiological_process
GO:0008595Anterior/posterior axis specification, embryoIEAbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0016020MembraneTAScellular_component
GO:0019211Phosphatase activator activityTASmolecular_function
GO:0030900Forebrain developmentIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046619Optic placode formation involved in camera-type eye formationIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050678Regulation of epithelial cell proliferationIEAbiological_process
GO:0060527Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19726839790.67271953570.85908363671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0681288727
GSE13712_SHEARUp0.0698006506
GSE13712_STATICUp0.0400559942
GSE19018Up0.0914644109
GSE19899_A1Up0.0704098553
GSE19899_A2Up0.1636131742
PubMed_21979375_A1Up0.1982549294
PubMed_21979375_A2Up0.3250483223
GSE35957Up0.3211823686
GSE36640Up0.8660801005
GSE54402Down-0.1459912103
GSE9593Up0.1860839176
GSE43922Down-0.1890446098
GSE24585Up0.3302692149
GSE37065Down-0.0198811415
GSE28863_A1Down-0.1229222599
GSE28863_A2Up0.0683682133
GSE28863_A3Down-0.8765464762
GSE28863_A4Up0.1923588223
GSE48662Up0.1676559121

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-548b-3pMIMAT0003254MIRT016233SequencingFunctional MTI (Weak)20371350
hsa-miR-186-5pMIMAT0000456MIRT021159SequencingFunctional MTI (Weak)20371350
hsa-miR-7-5pMIMAT0000252MIRT025864SequencingFunctional MTI (Weak)20371350
hsa-miR-101-3pMIMAT0000099MIRT027362SequencingFunctional MTI (Weak)20371350
hsa-miR-96-5pMIMAT0000095MIRT027936SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT028121SequencingFunctional MTI (Weak)20371350
hsa-miR-1303MIMAT0005891MIRT035895CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048233CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20032303PEA-15 binding prevented ERK1/2 membrane recruitment and threonine phosphorylation of fibroblast receptor substrate 2alpha (FRS2alpha), a key link in fibroblast growth factor (FGF) receptor activation of ERK1/2
20032303This reduced threonine phosphorylation led to increased FGF-induced tyrosine phosphorylation of FRS2alpha, thereby enhancing downstream signaling
20032303Conversely, short hairpin RNA-mediated depletion of endogenous PEA-15 led to reduced FRS2alpha tyrosine phosphorylation
20032303Thus, PEA-15 interrupts a negative feedback loop that terminates growth factor receptor signaling downstream of FRS2alpha
20032303This is the dominant mechanism by which PEA-15 activates ERK1/2 because genetic deletion of FRS2alpha blocked the capacity of PEA-15 to activate the MAP kinase pathway
20032303Thus, PEA-15 prevents ERK1/2 localization to the plasma membrane, thereby inhibiting ERK1/2-dependent threonine phosphorylation of FRS2alpha to promote activation of the ERK1/2 MAP kinase pathway
9570922Construction of cDNA libraries from two conditional cell lines and application of differential screening and subtractive hybridization techniques have resulted in the cloning of eight senescence-induced genes (SGP-2/Apo J, alpha 1-procollagen, osteonectin, fibronectin, SM22, cytochrome C oxidase, GTP-alpha, and a novel gene) and a senescence-repressed gene (FRS-2)
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