HCSGD entry for CFTR

1. General information

Official gene symbolCFTR
Entrez ID1080
Gene full namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Other gene symbolsABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005224ATP-binding and phosphorylation-dependent chloride channel activityTASmolecular_function
GO:0005254Chloride channel activityIDA IEAmolecular_function
GO:0005260Channel-conductance-controlling ATPase activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005769Early endosomeIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005902MicrovillusIEAcellular_component
GO:0006200ATP catabolic processNASbiological_process
GO:0006695Cholesterol biosynthetic processIEAbiological_process
GO:0006810TransportTASbiological_process
GO:0006833Water transportIEAbiological_process
GO:0007585Respiratory gaseous exchangeTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0015106Bicarbonate transmembrane transporter activityIEA ISSmolecular_function
GO:0015108Chloride transmembrane transporter activityIEA ISSmolecular_function
GO:0015705Iodide transportIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEA NAScellular_component
GO:0016324Apical plasma membraneIDA IEAcellular_component
GO:0016887ATPase activityIEAmolecular_function
GO:0019869Chloride channel inhibitor activityIDAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0030165PDZ domain bindingIDAmolecular_function
GO:0030301Cholesterol transportIEAbiological_process
GO:0030321Transepithelial chloride transportIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030659Cytoplasmic vesicle membraneIEAcellular_component
GO:0031205Endoplasmic reticulum Sec complexIDAcellular_component
GO:0031901Early endosome membraneIEAcellular_component
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0034220Ion transmembrane transportIDA ISS NAS TASbiological_process
GO:0034707Chloride channel complexIEAcellular_component
GO:0042311VasodilationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIEAmolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0048240Sperm capacitationIEA ISSbiological_process
GO:0051454Intracellular pH elevationIEA ISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060081Membrane hyperpolarizationIEA ISSbiological_process
GO:0071320Cellular response to cAMPIEA ISSbiological_process
GO:1902476Chloride transmembrane transportIDA ISS NAS TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60670487820.94676827250.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0476194668
GSE13712_SHEARDown-0.0707638317
GSE13712_STATICUp0.1234994175
GSE19018Up0.0999409504
GSE19899_A1Up0.0991410269
GSE19899_A2Down-0.0591242824
PubMed_21979375_A1Up0.0996578533
PubMed_21979375_A2Up0.0433516023
GSE35957Up0.0744964439
GSE36640Up0.2366153713
GSE54402Up0.1280985342
GSE9593Up0.1435517715
GSE43922Up0.0191984650
GSE24585Up0.0030434601
GSE37065Down-0.0468028445
GSE28863_A1Down-0.0097122337
GSE28863_A2Up0.0980499432
GSE28863_A3Up0.0884520699
GSE28863_A4Up0.0144289224
GSE48662Up0.0057631940

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1087004CHEMBL40519P13569
CHEMBL75680CHEMBL40519P13569
CHEMBL75680CHEMBL40519P13569
CHEMBL75680CHEMBL40519P13569
CHEMBL450222CHEMBL40519P13569
CHEMBL451791CHEMBL40519P13569
CHEMBL488824CHEMBL40519P13569
CHEMBL1222278CHEMBL40519P13569
CHEMBL1222403CHEMBL40519P13569
CHEMBL1080548CHEMBL40519P13569
CHEMBL470101CHEMBL40519P13569
CHEMBL461575CHEMBL40519P13569
CHEMBL1831059CHEMBL40519P13569
CHEMBL1222176CHEMBL40519P13569
CHEMBL513068CHEMBL40519P13569
CHEMBL1222276CHEMBL40519P13569
CHEMBL472190CHEMBL40519P13569
CHEMBL461941CHEMBL40519P13569
CHEMBL1222337CHEMBL40519P13569
CHEMBL509100CHEMBL40519P13569
CHEMBL488016CHEMBL40519P13569
CHEMBL460075CHEMBL40519P13569
CHEMBL1221481CHEMBL40519P13569
CHEMBL1222175CHEMBL40519P13569
CHEMBL1081471CHEMBL40519P13569
CHEMBL527432CHEMBL40519P13569
CHEMBL513552CHEMBL40519P13569
CHEMBL520739CHEMBL40519P13569
CHEMBL512539CHEMBL40519P13569
CHEMBL472528CHEMBL40519P13569
CHEMBL1222277CHEMBL40519P13569
CHEMBL470100CHEMBL40519P13569
CHEMBL511818CHEMBL40519P13569
CHEMBL1222340CHEMBL40519P13569
CHEMBL518808CHEMBL40519P13569
CHEMBL1221482CHEMBL40519P13569
CHEMBL512017CHEMBL40519P13569
CHEMBL513072CHEMBL40519P13569
CHEMBL452564CHEMBL40519P13569
CHEMBL1221531CHEMBL40519P13569
CHEMBL472192CHEMBL40519P13569
CHEMBL1087004CHEMBL40519P13569
CHEMBL1221532CHEMBL40519P13569
CHEMBL1831058CHEMBL40519P13569
CHEMBL486672CHEMBL40519P13569
CHEMBL472354CHEMBL40519P13569
CHEMBL1831069CHEMBL40519P13569
CHEMBL1221530CHEMBL40519P13569
CHEMBL1221483CHEMBL40519P13569
CHEMBL1087004CHEMBL40519P13569
CHEMBL461576CHEMBL40519P13569
CHEMBL451804CHEMBL40519P13569
CHEMBL1222405CHEMBL40519P13569
CHEMBL452052CHEMBL40519P13569
CHEMBL1831075CHEMBL40519P13569
CHEMBL513075CHEMBL40519P13569
CHEMBL486671CHEMBL40519P13569
CHEMBL1222406CHEMBL40519P13569
CHEMBL1831064CHEMBL40519P13569
CHEMBL488825CHEMBL40519P13569
CHEMBL461939CHEMBL40519P13569
CHEMBL461940CHEMBL40519P13569
CHEMBL487833CHEMBL40519P13569
CHEMBL461759CHEMBL40519P13569
CHEMBL1221533CHEMBL40519P13569
CHEMBL521207CHEMBL40519P13569
CHEMBL1222338CHEMBL40519P13569
CHEMBL1221484CHEMBL40519P13569
CHEMBL487654CHEMBL40519P13569
CHEMBL1831073CHEMBL40519P13569
CHEMBL1222339CHEMBL40519P13569
CHEMBL1831070CHEMBL40519P13569
CHEMBL451805CHEMBL40519P13569
CHEMBL1222404CHEMBL40519P13569
CHEMBL472355CHEMBL40519P13569
CHEMBL461375CHEMBL40519P13569
CHEMBL452565CHEMBL40519P13569
CHEMBL461381CHEMBL40519P13569
CHEMBL472191CHEMBL40519P13569
CHEMBL1779954CHEMBL40518P13569
CHEMBL1779950CHEMBL40518P13569
CHEMBL461939CHEMBL40518P13569
CHEMBL1779949CHEMBL40518P13569
CHEMBL1779953CHEMBL40518P13569
CHEMBL472CHEMBL40518P13569
CHEMBL461939CHEMBL40518P13569
CHEMBL1221576CHEMBL40518P13569
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  • Drugs

Name

Drug

Accession number

BumetanideDB00887 APRD00294
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
PhosphonoserineDB04522 EXPT02883
CrofelemerDB04941 -
IvacaftorDB08820 DB05989
LumacaftorDB09280 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-433-3pMIMAT0001627MIRT007361Luciferase reporter assayFunctional MTI23555973
hsa-miR-509-3pMIMAT0002881MIRT007363Luciferase reporter assayFunctional MTI23555973
hsa-miR-335-5pMIMAT0000765MIRT017834MicroarrayFunctional MTI (Weak)18185580
hsa-miR-132-3pMIMAT0000426MIRT021816MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23019197However, the ratios of cystic fibrosis transmembrane conductance regulator (CFTR) and solute-linked carrier 26 gene family (Slc26a6) mRNA expression in relation to cytokeratin-18 were not altered in duodenal mucosa
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