HCSGD entry for MTHFD2
1. General information
| Official gene symbol | MTHFD2 |
|---|---|
| Entrez ID | 10797 |
| Gene full name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
| Other gene symbols | NMDMC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0004329 | Formate-tetrahydrofolate ligase activity | IBA | molecular_function |
| GO:0004477 | Methenyltetrahydrofolate cyclohydrolase activity | IBA ISS | molecular_function |
| GO:0004487 | Methylenetetrahydrofolate dehydrogenase (NAD+) activity | IDA | molecular_function |
| GO:0004488 | Methylenetetrahydrofolate dehydrogenase (NADP+) activity | IDA IEA | molecular_function |
| GO:0005739 | Mitochondrion | IBA IEA ISS | cellular_component |
| GO:0005829 | Cytosol | IBA | cellular_component |
| GO:0006730 | One-carbon metabolic process | IBA | biological_process |
| GO:0009396 | Folic acid-containing compound biosynthetic process | IEA | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0042301 | Phosphate ion binding | IDA | molecular_function |
| GO:0046653 | Tetrahydrofolate metabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2740275673 | 0.0515558489 | 0.9703591551 | 0.4267300314 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6084061103 |
| GSE13712_SHEAR | Up | 0.6818679554 |
| GSE13712_STATIC | Up | 0.0693824510 |
| GSE19018 | Up | 1.0165023385 |
| GSE19899_A1 | Up | 0.0453063044 |
| GSE19899_A2 | Down | -0.4893220538 |
| PubMed_21979375_A1 | Up | 0.7677066842 |
| PubMed_21979375_A2 | Down | -0.5344535678 |
| GSE35957 | Down | -0.3088296211 |
| GSE36640 | Down | -0.7266172221 |
| GSE54402 | Down | -0.3457218243 |
| GSE9593 | Up | 0.2344881029 |
| GSE43922 | Up | 0.0511073494 |
| GSE24585 | Down | -0.4379600868 |
| GSE37065 | Down | -0.7675066757 |
| GSE28863_A1 | Up | 0.2051628739 |
| GSE28863_A2 | Down | -0.2103608945 |
| GSE28863_A3 | Up | 0.1304401220 |
| GSE28863_A4 | Down | -0.0067996958 |
| GSE48662 | Up | 0.0324348541 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tetrahydrofolic acid | DB00116 | NUTR00056 |
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001354 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT021039 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031940 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-421 | MIMAT0003339 | MIRT039360 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30e-5p | MIMAT0000692 | MIRT044162 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT044234 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047797 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
