HCSGD entry for SRSF10
1. General information
| Official gene symbol | SRSF10 |
|---|---|
| Entrez ID | 10772 |
| Gene full name | serine/arginine-rich splicing factor 10 |
| Other gene symbols | FUSIP1 FUSIP2 NSSR SFRS13 SFRS13A SRp38 SRrp40 TASR TASR1 TASR2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000244 | Spliceosomal tri-snRNP complex assembly | NAS | biological_process |
| GO:0000375 | RNA splicing, via transesterification reactions | IDA | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IDA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IC | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005737 | Cytoplasm | NAS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0006376 | MRNA splice site selection | IDA | biological_process |
| GO:0006406 | MRNA export from nucleus | NAS | biological_process |
| GO:0016482 | Cytoplasmic transport | IDA | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0048025 | Negative regulation of mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0050733 | RS domain binding | NAS | molecular_function |
| GO:0051082 | Unfolded protein binding | NAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9949525132 | 0.0097617986 | 0.9999902473 | 0.1955405632 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1433272411 |
| GSE13712_SHEAR | Down | -0.0322532454 |
| GSE13712_STATIC | Down | -0.0334457484 |
| GSE19018 | Down | -0.5727235811 |
| GSE19899_A1 | Down | -0.4042170337 |
| GSE19899_A2 | Down | -0.7520333687 |
| PubMed_21979375_A1 | Up | 0.0674559431 |
| PubMed_21979375_A2 | Down | -0.9168731341 |
| GSE35957 | Down | -0.1777287157 |
| GSE36640 | Down | -0.5681580541 |
| GSE54402 | Up | 0.0840490500 |
| GSE9593 | Down | -0.3700123266 |
| GSE43922 | Down | -0.1489110354 |
| GSE24585 | Down | -0.1670907482 |
| GSE37065 | Down | -0.1347753387 |
| GSE28863_A1 | Down | -0.2664650179 |
| GSE28863_A2 | Up | 0.0075761479 |
| GSE28863_A3 | Down | -0.3597047282 |
| GSE28863_A4 | Down | -0.3501451762 |
| GSE48662 | Down | -0.3072944868 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | MIRT003994 | Luciferase reporter assay//Reporter assay | Functional MTI | 18390668 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT043591 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047131 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048638 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | NA | hsa-miR-29c | 18390668 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
