HCSGD entry for ZMYND11
1. General information
| Official gene symbol | ZMYND11 |
|---|---|
| Entrez ID | 10771 |
| Gene full name | zinc finger, MYND-type containing 11 |
| Other gene symbols | BRAM1 BS69 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0043124 | Negative regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0046329 | Negative regulation of JNK cascade | IMP | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7133583299 | 0.4719044261 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0138377526 |
| GSE13712_SHEAR | Down | -0.1456886238 |
| GSE13712_STATIC | Down | -0.2826357665 |
| GSE19018 | Up | 0.0001367168 |
| GSE19899_A1 | Down | -0.2579608944 |
| GSE19899_A2 | Down | -0.2462796316 |
| PubMed_21979375_A1 | Up | 0.0444403227 |
| PubMed_21979375_A2 | Down | -0.1868223166 |
| GSE35957 | Up | 0.2009073586 |
| GSE36640 | Down | -0.0343812058 |
| GSE54402 | Up | 0.0622909721 |
| GSE9593 | Up | 0.2587006136 |
| GSE43922 | Down | -0.1816772478 |
| GSE24585 | Up | 0.0803021291 |
| GSE37065 | Down | -0.0236852918 |
| GSE28863_A1 | Up | 0.2889293650 |
| GSE28863_A2 | Down | -0.0062833877 |
| GSE28863_A3 | Down | -0.2631809544 |
| GSE28863_A4 | Up | 0.0963455397 |
| GSE48662 | Up | 0.3634481915 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-361-5p | MIMAT0000703 | MIRT020086 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024469 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026851 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043022 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045941 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046219 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046758 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19944017 | We found that the chromatin modifier-encoding genes Eu-HMTase1, ZMYND11, and RASA3 were overexpressed in adults |
| 17721438 | BS69 is involved in cellular senescence through the p53-p21Cip1 pathway |
| 17721438 | The multidomain-containing cellular protein BS69 interacts with adenovirus E1A and several other viral and cellular factors, and acts as a transcription repressor |
| 17721438 | Here, we show that BS69 is involved in the p53-p21Cip1-mediated senescence pathway |
| 17721438 | Knockdown of BS69 by RNA interference in human primary fibroblasts results in elevated levels of p21Cip1 and the appearance of several senescent markers, including enhanced senescence-associated beta-galactosidase activity and formation of senescence-associated heterochromatin foci |
| 17721438 | Importantly, knockdown of either p53 or p21Cip1, but not p16(INK4a) or Rb, allows cells to bypass premature senescence that is induced by BS69 knockdown |
| 17721438 | Furthermore, we show that BS69 forms complexes with both p53 and p400, and that BS69 associates with the p21Cip1 promoter through p53 |
| 17721438 | Together, our data indicate that BS69 is involved in cellular senescence mainly through the p53-p21Cip1 pathway |
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