HCSGD entry for CFL1
1. General information
| Official gene symbol | CFL1 |
|---|---|
| Entrez ID | 1072 |
| Gene full name | cofilin 1 (non-muscle) |
| Other gene symbols | CFL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001755 | Neural crest cell migration | IEA | biological_process |
| GO:0001842 | Neural fold formation | IEA | biological_process |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IEA | biological_process |
| GO:0006606 | Protein import into nucleus | IEA | biological_process |
| GO:0007010 | Cytoskeleton organization | IMP | biological_process |
| GO:0007266 | Rho protein signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009615 | Response to virus | IEP | biological_process |
| GO:0015629 | Actin cytoskeleton | IEA | cellular_component |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0022604 | Regulation of cell morphogenesis | IMP | biological_process |
| GO:0030010 | Establishment of cell polarity | IEA | biological_process |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0030030 | Cell projection organization | IEA | biological_process |
| GO:0030036 | Actin cytoskeleton organization | TAS | biological_process |
| GO:0030042 | Actin filament depolymerization | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030836 | Positive regulation of actin filament depolymerization | IEA | biological_process |
| GO:0030864 | Cortical actin cytoskeleton | IEA | cellular_component |
| GO:0031258 | Lamellipodium membrane | IEA | cellular_component |
| GO:0032587 | Ruffle membrane | IEA | cellular_component |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0043200 | Response to amino acid | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045792 | Negative regulation of cell size | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8237431139 | 0.6295090460 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0308652239 |
| GSE13712_SHEAR | Up | 0.0552264575 |
| GSE13712_STATIC | Up | 0.0246585342 |
| GSE19018 | Down | -0.0330196586 |
| GSE19899_A1 | Down | -0.0982318687 |
| GSE19899_A2 | Up | 0.2349472600 |
| PubMed_21979375_A1 | Up | 0.2498980681 |
| PubMed_21979375_A2 | Up | 0.1016465712 |
| GSE35957 | Up | 0.0051682808 |
| GSE36640 | Down | -0.1018360723 |
| GSE54402 | Up | 0.0528312518 |
| GSE9593 | Up | 0.0162796177 |
| GSE43922 | Up | 0.0299577946 |
| GSE24585 | Down | -0.2130138171 |
| GSE37065 | Down | -0.2860179696 |
| GSE28863_A1 | Up | 0.0984236225 |
| GSE28863_A2 | Down | -0.0408626882 |
| GSE28863_A3 | Up | 0.0866289160 |
| GSE28863_A4 | Up | 0.0297407618 |
| GSE48662 | Down | -0.2065564776 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Lauryl Dimethylamine-N-Oxide | DB04147 | EXPT02013 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025334 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036064 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037082 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041581 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041842 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043254 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19925638 | Identified proteins could be classified into several functional categories: (i) cytoskeletal regulators: CapG and cofilin 1; (ii) stress response and signal pathway proteins: TXNDC5 and RSU-1; and (iii) apoptosis proteins: Annexin V |
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