HCSGD entry for EBP
1. General information
| Official gene symbol | EBP |
|---|---|
| Entrez ID | 10682 |
| Gene full name | emopamil binding protein (sterol isomerase) |
| Other gene symbols | CDPX2 CHO2 CPX CPXD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000247 | C-8 sterol isomerase activity | IEA | molecular_function |
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0004769 | Steroid delta-isomerase activity | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IEA TAS | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006855 | Drug transmembrane transport | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008203 | Cholesterol metabolic process | TAS | biological_process |
| GO:0015238 | Drug transmembrane transporter activity | TAS | molecular_function |
| GO:0015893 | Drug transport | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016126 | Sterol biosynthetic process | IEA | biological_process |
| GO:0030097 | Hemopoiesis | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047750 | Cholestenol delta-isomerase activity | IEA | molecular_function |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9696222864 | 0.0203781011 | 0.9999902473 | 0.2762988163 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1140007815 |
| GSE13712_SHEAR | Down | -0.1533473857 |
| GSE13712_STATIC | Down | -0.1070009925 |
| GSE19018 | Down | -0.0817453245 |
| GSE19899_A1 | Down | -0.1229111239 |
| GSE19899_A2 | Down | -0.6833737229 |
| PubMed_21979375_A1 | Down | -0.8721214107 |
| PubMed_21979375_A2 | Down | -1.1626227652 |
| GSE35957 | Down | -0.5833343265 |
| GSE36640 | Down | -0.4854530473 |
| GSE54402 | Down | -0.0900814380 |
| GSE9593 | Down | -0.4851932876 |
| GSE43922 | Down | -0.1936824997 |
| GSE24585 | Down | -0.3959266717 |
| GSE37065 | Up | 0.1838824695 |
| GSE28863_A1 | Down | -0.1047913704 |
| GSE28863_A2 | Up | 0.3180167092 |
| GSE28863_A3 | Down | -0.3086310760 |
| GSE28863_A4 | Up | 0.2496680980 |
| GSE48662 | Down | -0.7158522246 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-218-5p | MIMAT0000275 | MIRT001061 | qRT-PCR//Western blot | Non-Functional MTI | 17998940 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040389 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042892 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049085 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25772238 | CCAAT/Enhancer Binding Protein (C/EBP) beta function is frequently deregulated in human malignancies and interestingly, androgen-sensitive PC cells express primarily the liver-enriched inhibitory protein isoform |
| 25772238 | CCAAT/Enhancer Binding Protein (C/EBP) beta function is frequently deregulated in human malignancies and interestingly, androgen-sensitive PC cells express primarily the liver-enriched inhibitory protein isoform |
| 15574883 | In silico promoter analysis of all differential genes predicted that nuclear factor-kappaB and C/EBP transcription factors are activated upon senescence, and we confirmed this by electrophoretic mobility shift assay |
| 15574883 | In silico promoter analysis of all differential genes predicted that nuclear factor-kappaB and C/EBP transcription factors are activated upon senescence, and we confirmed this by electrophoretic mobility shift assay |
Entries Per Page
Displaying Page of
