HCSGD entry for KHDRBS1
1. General information
| Official gene symbol | KHDRBS1 |
|---|---|
| Entrez ID | 10657 |
| Gene full name | KH domain containing, RNA binding, signal transduction associated 1 |
| Other gene symbols | Sam68 p62 p68 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | ISS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0005070 | SH3/SH2 adaptor activity | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006397 | MRNA processing | TAS | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | IDA | biological_process |
| GO:0008143 | Poly(A) binding | IDA | molecular_function |
| GO:0008266 | Poly(U) RNA binding | IDA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0009967 | Positive regulation of signal transduction | IPI | biological_process |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0031647 | Regulation of protein stability | IDA | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0045948 | Positive regulation of translational initiation | IDA | biological_process |
| GO:0046831 | Regulation of RNA export from nucleus | ISS | biological_process |
| GO:0046833 | Positive regulation of RNA export from nucleus | IDA | biological_process |
| GO:0070618 | Grb2-Sos complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9732242012 | 0.0351678394 | 0.9999902473 | 0.3549281825 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0462591000 |
| GSE13712_SHEAR | Down | -0.2014596177 |
| GSE13712_STATIC | Down | -0.1746459234 |
| GSE19018 | Down | -0.2309161940 |
| GSE19899_A1 | Down | -0.4111328842 |
| GSE19899_A2 | Down | -0.3304829868 |
| PubMed_21979375_A1 | Down | -0.3569473453 |
| PubMed_21979375_A2 | Down | -0.3091810206 |
| GSE35957 | Down | -0.7094447469 |
| GSE36640 | Down | -0.9456690739 |
| GSE54402 | Up | 0.2094164878 |
| GSE9593 | Down | -0.3034078739 |
| GSE43922 | Down | -0.3663043839 |
| GSE24585 | Up | 0.0117532694 |
| GSE37065 | Down | -0.1024549296 |
| GSE28863_A1 | Up | 0.3538931862 |
| GSE28863_A2 | Up | 0.4353673969 |
| GSE28863_A3 | Down | -0.0965544368 |
| GSE28863_A4 | Down | -0.0278707302 |
| GSE48662 | Down | -0.5680703786 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT037105 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040001 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040829 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046222 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047357 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049690 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17726370 | Therefore, the aims of the present study were to refine the feedback regulation of protein arginine methylation using one of the heavily methylated proteins, an RNA-binding protein Sam68, as a prototype, to elucidate the relations between Sam68 methylation and tyrosine phosphorylation and the role of methylation in RNA binding and subcellular distribution, as well as the cellular consequences of reduced protein methylation |
| 17726370 | Screening pro-atherogenic substances known to induce endothelial dysfunction showed that ADMA did not affect the level of arginine methylation of Sam68, whereas peroxynitrite was a strong inhibitor of methylation |
| 17726370 | Advanced glycation-modified collagen I, which accumulates in diabetes and induces formation of peroxynitrite and premature endothelial cell senescence, also inhibited arginine methylation of Sam68 |
| 17726370 | When the level of arginine methylation of Sam68 was pharmacologically reduced, this did not affect its RNA binding or degree of tyrosine phosphorylation, but resulted in the predominantly nuclear hypomethylation pattern |
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