HCSGD entry for PMVK
1. General information
| Official gene symbol | PMVK |
|---|---|
| Entrez ID | 10654 |
| Gene full name | phosphomevalonate kinase |
| Other gene symbols | HUMPMKI PMK PMKA PMKASE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004631 | Phosphomevalonate kinase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IDA TAS | biological_process |
| GO:0016126 | Sterol biosynthetic process | IDA | biological_process |
| GO:0019287 | Isopentenyl diphosphate biosynthetic process, mevalonate pathway | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0070723 | Response to cholesterol | IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9797218875 | 0.0184371414 | 0.9999902473 | 0.2657634173 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2778617124 |
| GSE13712_SHEAR | Down | -0.2572760528 |
| GSE13712_STATIC | Down | -0.1986134543 |
| GSE19018 | Down | -0.4713716130 |
| GSE19899_A1 | Down | -0.4639548420 |
| GSE19899_A2 | Down | -0.6729499296 |
| PubMed_21979375_A1 | Down | -1.6405317821 |
| PubMed_21979375_A2 | Down | -1.3659778758 |
| GSE35957 | Down | -0.3510207035 |
| GSE36640 | Down | -0.0851851399 |
| GSE54402 | Down | -0.5349399332 |
| GSE9593 | Down | -0.1957016992 |
| GSE43922 | Up | 0.0539786878 |
| GSE24585 | Up | 0.0115454999 |
| GSE37065 | Down | -0.1389818265 |
| GSE28863_A1 | Down | -0.0858508563 |
| GSE28863_A2 | Down | -0.0128173803 |
| GSE28863_A3 | Down | -0.1822143270 |
| GSE28863_A4 | Down | -0.1962710894 |
| GSE48662 | Up | 0.2369618445 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
