HCSGD entry for IGF2BP1
1. General information
| Official gene symbol | IGF2BP1 |
|---|---|
| Entrez ID | 10642 |
| Gene full name | insulin-like growth factor 2 mRNA binding protein 1 |
| Other gene symbols | CRD-BP CRDBP IMP-1 IMP1 VICKZ1 ZBP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003729 | MRNA binding | IDA | molecular_function |
| GO:0003730 | MRNA 3'-UTR binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010494 | Cytoplasmic stress granule | IDA | cellular_component |
| GO:0010610 | Regulation of mRNA stability involved in response to stress | IMP | biological_process |
| GO:0017148 | Negative regulation of translation | IDA | biological_process |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0030175 | Filopodium | IEA | cellular_component |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0030426 | Growth cone | IEA | cellular_component |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0042035 | Regulation of cytokine biosynthetic process | IC | biological_process |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045182 | Translation regulator activity | IDA | molecular_function |
| GO:0048027 | MRNA 5'-UTR binding | IDA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051028 | MRNA transport | IEA | biological_process |
| GO:0070934 | CRD-mediated mRNA stabilization | IDA | biological_process |
| GO:0070937 | CRD-mediated mRNA stability complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2715256601 | 0.3937615326 | 0.9684931852 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0112444688 |
| GSE13712_SHEAR | Down | -0.0237774245 |
| GSE13712_STATIC | Down | -0.0914585793 |
| GSE19018 | Down | -0.0694396921 |
| GSE19899_A1 | Down | -0.0113432610 |
| GSE19899_A2 | Up | 0.2146318165 |
| PubMed_21979375_A1 | Down | -0.0556917337 |
| PubMed_21979375_A2 | Up | 0.4816527996 |
| GSE35957 | Up | 0.0855285094 |
| GSE36640 | Down | -0.6539401078 |
| GSE54402 | Up | 0.6370495618 |
| GSE9593 | Up | 0.0773057487 |
| GSE43922 | Up | 0.0675514442 |
| GSE24585 | Down | -0.0177516422 |
| GSE37065 | Up | 0.1718006052 |
| GSE28863_A1 | Up | 0.2618257800 |
| GSE28863_A2 | Down | -0.3407091237 |
| GSE28863_A3 | Down | -0.6855837136 |
| GSE28863_A4 | Up | 0.0714048675 |
| GSE48662 | Down | -0.1134964987 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001621 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-let-7g-5p | MIMAT0000414 | MIRT003831 | Western blot//Reporter assay;Other | Functional MTI | 18413726 |
| hsa-let-7g-5p | MIMAT0000414 | MIRT003831 | qRT-PCR;Other | Functional MTI (Weak) | 21618519 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT019663 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026098 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032186 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036388 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036910 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039632 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042104 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044181 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044393 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT051402 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7g-5p | MIMAT0000414 | NA | hsa-let-7g | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides} | 18413726 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21204633 | In this study, therefore, we report, for the first time, the expression of Crd-bp/Imp1 and Dazl in BM-MSCs |
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