HCSGD entry for LEFTY1
1. General information
| Official gene symbol | LEFTY1 |
|---|---|
| Entrez ID | 10637 |
| Gene full name | left-right determination factor 1 |
| Other gene symbols | LEFTB LEFTYB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0003007 | Heart morphogenesis | ISS | biological_process |
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005160 | Transforming growth factor beta receptor binding | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0007368 | Determination of left/right symmetry | ISS | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0016049 | Cell growth | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6455477299 | 0.5345495840 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1204011214 |
| GSE13712_SHEAR | Up | 0.2913572835 |
| GSE13712_STATIC | Up | 0.0957663395 |
| GSE19018 | Down | -0.0809995918 |
| GSE19899_A1 | Down | -0.0325504203 |
| GSE19899_A2 | Up | 0.3384233512 |
| PubMed_21979375_A1 | Up | 0.1070241986 |
| PubMed_21979375_A2 | Down | -0.2061359090 |
| GSE35957 | Down | -0.0041993326 |
| GSE36640 | Down | -0.0050858157 |
| GSE54402 | Up | 0.0036657812 |
| GSE9593 | Up | 0.1290442291 |
| GSE43922 | Up | 0.0493061088 |
| GSE24585 | Up | 0.0183158472 |
| GSE37065 | Down | -0.0626977459 |
| GSE28863_A1 | Down | -0.4734013504 |
| GSE28863_A2 | Down | -0.1845373450 |
| GSE28863_A3 | Up | 0.2590345903 |
| GSE28863_A4 | Down | -0.1379585399 |
| GSE48662 | Down | -0.0871953602 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-302a-3p | MIMAT0000684 | MIRT005556 | Immunohistochemistry//Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blot | Functional MTI | 21266536 |
| hsa-miR-302d-3p | MIMAT0000718 | MIRT005633 | Immunohistochemistry//Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blo | Functional MTI | 21266536 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-302a-3p | MIMAT0000684 | 1 | hsa-miR-302a | 19386261 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
