HCSGD entry for RBCK1
1. General information
| Official gene symbol | RBCK1 |
|---|---|
| Entrez ID | 10616 |
| Gene full name | RanBP-type and C3HC4-type zinc finger containing 1 |
| Other gene symbols | C20orf18 HOIL-1 HOIL1 RBCK2 RNF54 UBCE7IP3 XAP3 XAP4 ZRANB4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0042346 | Positive regulation of NF-kappaB import into nucleus | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IDA IEA | biological_process |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IMP | biological_process |
| GO:0050852 | T cell receptor signaling pathway | IDA | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0071797 | LUBAC complex | IDA IEA | cellular_component |
| GO:0097039 | Protein linear polyubiquitination | IDA | biological_process |
| GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0558780290 | 0.8695150716 | 0.5145136872 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4989300847 |
| GSE13712_SHEAR | Up | 0.1973990140 |
| GSE13712_STATIC | Up | 0.3169007028 |
| GSE19018 | Up | 0.4672494174 |
| GSE19899_A1 | Down | -0.3623468817 |
| GSE19899_A2 | Up | 0.3773450879 |
| PubMed_21979375_A1 | Up | 0.7986664679 |
| PubMed_21979375_A2 | Up | 0.9290140308 |
| GSE35957 | Down | -0.7233835859 |
| GSE36640 | Up | 0.1895615601 |
| GSE54402 | Up | 0.1226835366 |
| GSE9593 | Up | 0.1963342144 |
| GSE43922 | Down | -0.0547005504 |
| GSE24585 | Up | 0.1992429377 |
| GSE37065 | Up | 0.1250461062 |
| GSE28863_A1 | Up | 0.0718143985 |
| GSE28863_A2 | Down | -0.1888592594 |
| GSE28863_A3 | Down | -0.0519100895 |
| GSE28863_A4 | Down | -0.0790151201 |
| GSE48662 | Up | 0.6012898085 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019076 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023193 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025392 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
