HCSGD entry for PDLIM5
1. General information
| Official gene symbol | PDLIM5 |
|---|---|
| Entrez ID | 10611 |
| Gene full name | PDZ and LIM domain 5 |
| Other gene symbols | ENH ENH1 LIM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA ISS | molecular_function |
| GO:0005080 | Protein kinase C binding | IEA ISS | molecular_function |
| GO:0005829 | Cytosol | IEA ISS | cellular_component |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0014069 | Postsynaptic density | IEA ISS | cellular_component |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0016020 | Membrane | IEA ISS | cellular_component |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0042805 | Actinin binding | IEA ISS | molecular_function |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0045211 | Postsynaptic membrane | IEA | cellular_component |
| GO:0047485 | Protein N-terminus binding | IEA | molecular_function |
| GO:0051963 | Regulation of synapse assembly | IEA ISS | biological_process |
| GO:0061001 | Regulation of dendritic spine morphogenesis | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9438533908 | 0.0201850424 | 0.9999902473 | 0.2752800518 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.1174550020 |
| GSE13712_SHEAR | Up | 0.0416338197 |
| GSE13712_STATIC | Down | -0.3106790478 |
| GSE19018 | Down | -0.5183343008 |
| GSE19899_A1 | Down | -0.1721338642 |
| GSE19899_A2 | Down | -0.1551579665 |
| PubMed_21979375_A1 | Down | -0.0312336701 |
| PubMed_21979375_A2 | Down | -0.1919165408 |
| GSE35957 | Up | 0.1703858599 |
| GSE36640 | Down | -0.2987914730 |
| GSE54402 | Down | -0.0167496346 |
| GSE9593 | Down | -0.1444451112 |
| GSE43922 | Up | 0.3169795206 |
| GSE24585 | Up | 0.4502068054 |
| GSE37065 | Down | -0.0270287709 |
| GSE28863_A1 | Down | -0.1142534862 |
| GSE28863_A2 | Down | -0.5400237043 |
| GSE28863_A3 | Down | -0.7588949625 |
| GSE28863_A4 | Down | -0.0927657115 |
| GSE48662 | Down | -0.2462056176 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001527 | pSILAC | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001527 | Western blot | Functional MTI | 20584899 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032035 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051014 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25346044 | Among these CNVs, LIM and senescent cell antigen-like domain 2 (PINCH-2) showed copy number amplification and upregulation of mRNA in the nonrelapsed group compared to the systemic relapse group |
| 14744771 | Nuclear accumulation of globular actin (G-actin) and dephosphorylated cofilin was highly significant in the senescent HDF cells, accompanied with inhibition of LIM kinase (LIMK) -1 activity |
| 9597752 | The hic-5 gene encodes the novel LIM protein which has been implicated in cellular senescence and differentiation processes |
| 9032249 | Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts |
| 9032249 | The hic-5 gene encodes a novel protein with Zn finger-like (LIM) motifs, the expression of which increases during cellular senescence |
| 7929412 | Analysis of this cDNA renamed hic (hydrogen peroxide-inducible clone)-5 suggested that Hic-5 protein has four LIM motifs, each of which contained two (or one) putative zinc fingers |
| 7517666 | A new LIM protein containing an autoepitope homologous to "senescent cell antigen" |
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