HCSGD entry for ERN2

1. General information

Official gene symbolERN2
Entrez ID10595
Gene full nameendoplasmic reticulum to nucleus signaling 2
Other gene symbolsIRE1-BETA IRE1b
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0004519Endonuclease activityIDAmolecular_function
GO:0004540Ribonuclease activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006397MRNA processingIEAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016075RRNA catabolic processIDAbiological_process
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0030263Apoptotic chromosome condensationIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0070059Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressIEAbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75265401390.78507807450.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0650101281
GSE13712_SHEARUp0.2825248288
GSE13712_STATICDown-0.0062809695
GSE19018Down-0.0218009562
GSE19899_A1Down-0.0378891236
GSE19899_A2Down-0.0293306006
PubMed_21979375_A1Down-0.2780099296
PubMed_21979375_A2Up0.0635609215
GSE35957Up0.2150790141
GSE36640Up0.0213391200
GSE54402Down-0.0445508176
GSE9593Up0.0244179375
GSE43922Up0.0270150277
GSE24585Down-0.0790475518
GSE37065Down-0.0325833664
GSE28863_A1Down-0.0932264131
GSE28863_A2Down-0.0000761346
GSE28863_A3Up0.2896291942
GSE28863_A4Up0.1320821730
GSE48662Down-0.0388724558

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.