HCSGD entry for TXNRD2
1. General information
| Official gene symbol | TXNRD2 |
|---|---|
| Entrez ID | 10587 |
| Gene full name | thioredoxin reductase 2 |
| Other gene symbols | SELZ TR TR-BETA TR3 TRXR2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000305 | Response to oxygen radical | TAS | biological_process |
| GO:0004791 | Thioredoxin-disulfide reductase activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0030097 | Hemopoiesis | IEA | biological_process |
| GO:0045454 | Cell redox homeostasis | IEA | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0050661 | NADP binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2938629231 | 0.9508167471 | 0.9939905447 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0030756912 |
| GSE13712_SHEAR | Up | 0.5866003599 |
| GSE13712_STATIC | Up | 0.1356272442 |
| GSE19018 | Up | 0.1890977277 |
| GSE19899_A1 | Down | -0.0674344588 |
| GSE19899_A2 | Up | 0.6600430264 |
| PubMed_21979375_A1 | Up | 0.3224407391 |
| PubMed_21979375_A2 | Down | -0.0233532312 |
| GSE35957 | Down | -0.1540419196 |
| GSE36640 | Up | 0.0762310507 |
| GSE54402 | Down | -0.0587499572 |
| GSE9593 | Up | 0.1616610325 |
| GSE43922 | Up | 0.0498130125 |
| GSE24585 | Up | 0.1896055051 |
| GSE37065 | Down | -0.0317419539 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0873464582 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| motexafin gadolinium | DB05428 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-3p | MIMAT0000071 | MIRT005748 | Luciferase reporter assay//Quantitative proteomic approach//Western blot | Functional MTI | 21203553 |
| hsa-miR-671-5p | MIMAT0003880 | MIRT039271 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044324 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
