HCSGD entry for CENPA
1. General information
| Official gene symbol | CENPA |
|---|---|
| Entrez ID | 1058 |
| Gene full name | centromere protein A |
| Other gene symbols | CENP-A CenH3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000132 | Establishment of mitotic spindle orientation | IMP | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000775 | Chromosome, centromeric region | IDA | cellular_component |
| GO:0000778 | Condensed nuclear chromosome kinetochore | IDA | cellular_component |
| GO:0000780 | Condensed nuclear chromosome, centromeric region | IDA | cellular_component |
| GO:0000786 | Nucleosome | IEA | cellular_component |
| GO:0000939 | Condensed chromosome inner kinetochore | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006334 | Nucleosome assembly | IEA TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0034080 | CENP-A containing nucleosome assembly at centromere | TAS | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0051382 | Kinetochore assembly | IDA | biological_process |
| GO:0071459 | Protein localization to chromosome, centromeric region | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9865435698 | 0.0004103909 | 0.9999902473 | 0.0380348592 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3351747949 |
| GSE13712_SHEAR | Down | -0.0163445450 |
| GSE13712_STATIC | Down | -0.4131253150 |
| GSE19018 | Down | -0.0325652830 |
| GSE19899_A1 | Down | -0.8137814279 |
| GSE19899_A2 | Down | -3.7577659085 |
| PubMed_21979375_A1 | Down | -1.3705329901 |
| PubMed_21979375_A2 | Down | -2.9193875586 |
| GSE35957 | Down | -1.8420494508 |
| GSE36640 | Down | -2.8708657977 |
| GSE54402 | Down | -0.6583593382 |
| GSE9593 | Down | -0.5470912585 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.2746013477 |
| GSE28863_A2 | Up | 0.9798638293 |
| GSE28863_A3 | Down | -0.1803430247 |
| GSE28863_A4 | Up | 0.1208974052 |
| GSE48662 | Down | -1.7116304283 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024281 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026545 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23292286 | Holliday junction recognition protein (HJURP), a centromere protein-A (CENP-A) histone chaperone, mediates centromere-specific assembly of CENP-A nucleosome, contributing to high-fidelity chromosome segregation during cell division |
| 22132080 | RESULTS: Analysis of heterochromatin distribution in bovine senescent cells using fluorescent in situ hybridization for pericentric chromosomal regions, immunostaining of H3K9me3, centromeric proteins CENP A/B and DNA methylation showed a lower level of heterochromatin condensation as compared to young cells |
| 20160010 | CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses |
| 20160010 | We examined chromatin structure in senescent human primary fibroblasts and found that CENP-A protein levels are diminished in senescent cells |
| 20160010 | Senescence-associated reduction of CENP-A is caused by transcriptional and posttranslational control |
| 20160010 | Surprisingly, forced reduction of CENP-A by short-hairpin RNA was found to cause premature senescence in human primary fibroblasts |
| 20160010 | This premature senescence is dependent on a tumor suppressor, p53, but not on p16(INK4a)-Rb; the depletion of CENP-A in p53-deficient cells results in aberrant mitosis with chromosome missegregation |
| 20160010 | We propose that p53-dependent senescence that arises from CENP-A reduction acts as a "self-defense mechanism" to prevent centromere-defective cells from undergoing mitotic proliferation that potentially leads to massive generation of aneuploid cells |
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