HCSGD entry for SIVA1
1. General information
| Official gene symbol | SIVA1 |
|---|---|
| Entrez ID | 10572 |
| Gene full name | SIVA1, apoptosis-inducing factor |
| Other gene symbols | CD27BP SIVA Siva-1 Siva-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001618 | Virus receptor activity | ISS | molecular_function |
| GO:0005175 | CD27 receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006924 | Activation-induced cell death of T cells | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0009615 | Response to virus | ISS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0032088 | Negative regulation of NF-kappaB transcription factor activity | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0097191 | Extrinsic apoptotic signaling pathway | IDA | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | IDA | biological_process |
| GO:1901030 | Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9721712853 | 0.0393475628 | 0.9999902473 | 0.3738870758 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1048364037 |
| GSE13712_SHEAR | Down | -0.4744178482 |
| GSE13712_STATIC | Down | -0.3326002902 |
| GSE19018 | Up | 0.1110212323 |
| GSE19899_A1 | Down | -0.5224460774 |
| GSE19899_A2 | Down | -0.3263318163 |
| PubMed_21979375_A1 | Up | 0.1560391507 |
| PubMed_21979375_A2 | Down | -0.7485742409 |
| GSE35957 | Down | -0.7639330333 |
| GSE36640 | Down | -0.4698982862 |
| GSE54402 | Up | 0.1519221143 |
| GSE9593 | Down | -0.3181323752 |
| GSE43922 | Down | -0.0004987458 |
| GSE24585 | Down | -0.3453231514 |
| GSE37065 | Down | -0.3032328176 |
| GSE28863_A1 | Down | -0.0978527718 |
| GSE28863_A2 | Down | -0.0350103353 |
| GSE28863_A3 | Up | 0.1621441476 |
| GSE28863_A4 | Up | 0.0277531903 |
| GSE48662 | Down | -0.0470165907 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019564 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
