HCSGD entry for HYOU1
1. General information
| Official gene symbol | HYOU1 |
|---|---|
| Entrez ID | 10525 |
| Gene full name | hypoxia up-regulated 1 |
| Other gene symbols | GRP-170 Grp170 HSP12A ORP-150 ORP150 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002931 | Response to ischemia | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005783 | Endoplasmic reticulum | TAS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0071682 | Endocytic vesicle lumen | TAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4549288819 | 0.2036252232 | 0.9999902473 | 0.8737560320 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3120727193 |
| GSE13712_SHEAR | Down | -0.2820622812 |
| GSE13712_STATIC | Down | -0.1972413091 |
| GSE19018 | Down | -0.4617409259 |
| GSE19899_A1 | Up | 0.0113077630 |
| GSE19899_A2 | Down | -0.2571752190 |
| PubMed_21979375_A1 | Up | 0.8590501563 |
| PubMed_21979375_A2 | Up | 0.1004186840 |
| GSE35957 | Down | -0.6280524046 |
| GSE36640 | Down | -0.1740269032 |
| GSE54402 | Up | 0.3404355043 |
| GSE9593 | Down | -0.4456692333 |
| GSE43922 | Up | 0.0270071500 |
| GSE24585 | Down | -0.0987882991 |
| GSE37065 | Down | -0.2276041581 |
| GSE28863_A1 | Up | 0.1457159246 |
| GSE28863_A2 | Up | 0.7383672599 |
| GSE28863_A3 | Down | -0.2582046278 |
| GSE28863_A4 | Up | 0.0184198501 |
| GSE48662 | Up | 0.0267657578 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016306 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016306 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016902 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036087 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037898 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038859 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039029 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040395 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041955 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047102 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23757447 | Low-glucose medium induces ORP150 expression and exerts inhibitory effect on apoptosis and senescence of human breast MCF7 cells |
| 23757447 | Glucose deprivation is a factor evoking endoplasmic reticulum (ER) stress and induction of expression of an oxygen-regulated protein of 150 kDa (ORP150) |
| 23757447 | We studied the effect of inducible overexpression of ORP150 on senescence and apoptosis of human breast carcinoma cells (MCF7) and human skin fibroblasts |
| 23757447 | We found an inhibitory effect of ORP150 on apoptosis and senescence of MCF7 cells, but not fibroblasts in ER stress conditions |
| 23757447 | We suggest that ORP150 induction in cancer cells can promote tumour progression and may be a major cause of their resistance to chemotherapeutics |
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