HCSGD entry for CARM1

1. General information

Official gene symbolCARM1
Entrez ID10498
Gene full namecoactivator-associated arginine methyltransferase 1
Other gene symbolsPRMT4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003420Regulation of growth plate cartilage chondrocyte proliferationIEAbiological_process
GO:0003713Transcription coactivator activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolISScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedISSbiological_process
GO:0006479Protein methylationIEAbiological_process
GO:0008013Beta-catenin bindingTASmolecular_function
GO:0008168Methyltransferase activityIEAmolecular_function
GO:0008276Protein methyltransferase activityISSmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009405PathogenesisIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016274Protein-arginine N-methyltransferase activityISSmolecular_function
GO:0016571Histone methylationIDA ISSbiological_process
GO:0030374Ligand-dependent nuclear receptor transcription coactivator activityISSmolecular_function
GO:0030520Intracellular estrogen receptor signaling pathwayIEAbiological_process
GO:0032091Negative regulation of protein bindingIEAbiological_process
GO:0033146Regulation of intracellular estrogen receptor signaling pathwayISSbiological_process
GO:0034970Histone H3-R2 methylationIMPbiological_process
GO:0034971Histone H3-R17 methylationISSbiological_process
GO:0035242Protein-arginine omega-N asymmetric methyltransferase activityISSmolecular_function
GO:0035642Histone methyltransferase activity (H3-R17 specific)ISSmolecular_function
GO:0042054Histone methyltransferase activityIDAmolecular_function
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045600Positive regulation of fat cell differentiationISSbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0060350Endochondral bone morphogenesisIEAbiological_process
GO:0070577Histone acetyl-lysine bindingISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92835018050.24398853010.99999024730.9515516521

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922Down-0.2036211854
GSE24585Down-0.8265212678
GSE37065Down-0.3762315160
GSE28863_A1Up0.2624416529
GSE28863_A2Up0.4423638986
GSE28863_A3Down-0.1704792185
GSE28863_A4Up0.0032793470
GSE48662Down-0.1187672225

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92a-3pMIMAT0000092MIRT049639CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051469CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25906418Coactivator-associated arginine methyltransferase-1 (CARM1) regulates histone methylation and the transcription of genes involved in senescence, proliferation, and differentiation
25906418Complete loss of CARM1 leads to disrupted differentiation and maturation of alveolar epithelial type II (ATII) cells
25906418We thus hypothesized that CARM1 regulates the development and progression of emphysema
25906418To address this, we investigated the contribution of CARM1 to alveolar rarefication using the mouse model of elastase-induced emphysema in vivo and small interfering (si)RNA-mediated knockdown in ATII-like LA4 cells in vitro
25906418We demonstrate that emphysema progression in vivo is associated with a time-dependent down-regulation of CARM1
25906418Importantly, elastase-treated CARM1 haploinsufficient mice show significantly increased airspace enlargement (52
25906418The knockdown of CARM1 in LA4 cells led to decreased sirtuin 1 expression (0
25906418We further demonstrated that CARM1 haploinsufficiency impairs transdifferentiation and wound healing (32
25906418Overall, these results reveal a novel function of CARM1 in regulating emphysema development and premature lung aging via alveolar senescence as well as impaired regeneration, repair, and differentiation of ATII cells
18676353When the expression of protein arginine methyltransferases (PRMTs), namely PRMT1, PRMT4, PRMT5 and PRMT6 was examined, a significant reduction was found in replicatively senescent cells as well as their catalytic activities against histone mixtures compared with the young cells
18676353Furthermore, when the endogenous level of arginine-dimethylated proteins was determined, asymmetric modification (the product of type I PRMTs including PRMT1, PRMT4 and PRMT6) was markedly down-regulated
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