HCSGD entry for VTI1B
1. General information
| Official gene symbol | VTI1B |
|---|---|
| Entrez ID | 10490 |
| Gene full name | vesicle transport through interaction with t-SNAREs 1B |
| Other gene symbols | VTI1 VTI1-LIKE VTI1L VTI2 v-SNARE vti1-rp1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000046 | Autophagic vacuole fusion | IMP | biological_process |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0006904 | Vesicle docking involved in exocytosis | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016192 | Vesicle-mediated transport | TAS | biological_process |
| GO:0031201 | SNARE complex | IEA | cellular_component |
| GO:0031902 | Late endosome membrane | IDA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0061025 | Membrane fusion | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4935324380 | 0.2715781467 | 0.9999902473 | 0.9968061062 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1184933281 |
| GSE13712_SHEAR | Down | -0.3786881882 |
| GSE13712_STATIC | Down | -0.2473188143 |
| GSE19018 | Up | 0.2263013907 |
| GSE19899_A1 | Down | -0.5346308906 |
| GSE19899_A2 | Down | -0.3927499097 |
| PubMed_21979375_A1 | Down | -0.3766686446 |
| PubMed_21979375_A2 | Down | -0.2979884314 |
| GSE35957 | Up | 0.4973267340 |
| GSE36640 | Up | 0.7198598924 |
| GSE54402 | Up | 0.0752997849 |
| GSE9593 | Up | 0.6548966267 |
| GSE43922 | Down | -0.5163366771 |
| GSE24585 | Down | -0.1990829494 |
| GSE37065 | Down | -0.0788988886 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0481986841 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001397 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001397 | Microarray | Functional MTI (Weak) | 21199864 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028226 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 9636656 | A hVti1 homologue: its expression depends on population doubling levels in both normal and SV40-transformed human fibroblasts |
| 9636656 | The deduced amino acid sequence of N-10 was identical to the recently reported hVti1 gene except in one amino acid: Asp24(GAC) was ours and Asn24 (AAC) was reported |
| 9636656 | As hVti1 protein was suggested to be involved in the vesicle transport process, the homologue may be concerned with increased secretion of extracellular matrix and various cytokines associated with cellular senescence |
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