HCSGD entry for MERTK

1. General information

Official gene symbolMERTK
Entrez ID10461
Gene full namec-mer proto-oncogene tyrosine kinase
Other gene symbolsMER RP38 c-mer
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001750Photoreceptor outer segmentIEAcellular_component
GO:0001779Natural killer cell differentiationIEAbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006909PhagocytosisIMPbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016028RhabdomereIDAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0030168Platelet activationIEAbiological_process
GO:0032940Secretion by cellIEAbiological_process
GO:0034446Substrate adhesion-dependent cell spreadingIEAbiological_process
GO:0043277Apoptotic cell clearanceIEAbiological_process
GO:0043491Protein kinase B signalingIEAbiological_process
GO:0050766Positive regulation of phagocytosisIDAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051250Negative regulation of lymphocyte activationIEAbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060068Vagina developmentIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08206394130.93515932910.60402824381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0005735397
GSE13712_SHEARUp0.1510311190
GSE13712_STATICUp0.2579958053
GSE19018Up0.0109176951
GSE19899_A1Up0.0080295717
GSE19899_A2Up0.0933362518
PubMed_21979375_A1Down-0.3688228159
PubMed_21979375_A2Down-0.2245925245
GSE35957Down-0.0434357075
GSE36640Up0.0038287544
GSE54402Up0.0646696906
GSE9593Up0.1005680692
GSE43922Up0.0234834639
GSE24585Up3.1438508900
GSE37065Up0.3552453341
GSE28863_A1Down-0.0363974349
GSE28863_A2Up0.2150281896
GSE28863_A3Up0.1051709948
GSE28863_A4Up0.0135289046
GSE48662Up0.1193918522

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1908392CHEMBL53319Q12866
CHEMBL491473CHEMBL53319Q12866
CHEMBL24828CHEMBL53319Q12866
CHEMBL103667CHEMBL53319Q12866
CHEMBL574738CHEMBL53319Q12866
CHEMBL1908394CHEMBL53319Q12866
CHEMBL223360CHEMBL53319Q12866
CHEMBL191003CHEMBL53319Q12866
CHEMBL522892CHEMBL53319Q12866
CHEMBL1241674CHEMBL53319Q12866
CHEMBL1289926CHEMBL53319Q12866
CHEMBL601719CHEMBL53319Q12866
CHEMBL608533CHEMBL53319Q12866
CHEMBL288441CHEMBL53319Q12866
CHEMBL1908397CHEMBL53319Q12866
CHEMBL259084CHEMBL53319Q12866
CHEMBL535CHEMBL53319Q12866
CHEMBL223360CHEMBL53319Q12866
CHEMBL1822792CHEMBL53319Q12866
CHEMBL428690CHEMBL53319Q12866
CHEMBL572878CHEMBL53319Q12866
CHEMBL259084CHEMBL53319Q12866
CHEMBL428690CHEMBL53319Q12866
CHEMBL1908393CHEMBL53319Q12866
CHEMBL509032CHEMBL53319Q12866
CHEMBL1721885CHEMBL53319Q12866
CHEMBL1721885CHEMBL53319Q12866
CHEMBL1336CHEMBL53319Q12866
CHEMBL475251CHEMBL53319Q12866
CHEMBL1336CHEMBL53319Q12866
CHEMBL607707CHEMBL53319Q12866
CHEMBL1908395CHEMBL53319Q12866
CHEMBL162CHEMBL53319Q12866
CHEMBL603469CHEMBL53319Q12866
CHEMBL162CHEMBL53319Q12866
CHEMBL535CHEMBL53319Q12866
CHEMBL1287853CHEMBL53319Q12866
CHEMBL124660CHEMBL53319Q12866
CHEMBL553CHEMBL53319Q12866
CHEMBL180022CHEMBL53319Q12866
CHEMBL513909CHEMBL53319Q12866
CHEMBL572878CHEMBL53319Q12866
CHEMBL477772CHEMBL53319Q12866
CHEMBL24828CHEMBL53319Q12866
CHEMBL103667CHEMBL53319Q12866
CHEMBL574738CHEMBL53319Q12866
CHEMBL477772CHEMBL53319Q12866
CHEMBL464552CHEMBL53319Q12866
CHEMBL1908396CHEMBL53319Q12866
CHEMBL608533CHEMBL53319Q12866
CHEMBL522892CHEMBL53319Q12866
CHEMBL450786CHEMBL53319Q12866
CHEMBL495727CHEMBL53318Q12866
CHEMBL603469CHEMBL53318Q12866
CHEMBL535CHEMBL53318Q12866
CHEMBL608533CHEMBL53318Q12866
CHEMBL1336CHEMBL53318Q12866
CHEMBL460702CHEMBL53318Q12866
CHEMBL1933550CHEMBL53318Q12866
CHEMBL1933538CHEMBL53318Q12866
CHEMBL1933551CHEMBL53318Q12866
CHEMBL1933552CHEMBL53318Q12866
Entries Per Page
Displaying Page of

  • Drugs

Name

Drug

Accession number

2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINEDB08325 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-126-3pMIMAT0000445MIRT006545ELISA//Flow//Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22170610
hsa-miR-335-5pMIMAT0000765MIRT002429Luciferase reporter assay//Microarray//Microarray;OtherFunctional MTI18185580
hsa-miR-16-5pMIMAT0000069MIRT031965ProteomicsFunctional MTI (Weak)18668040
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27783662MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme
27783662BACKGROUND: MER receptor tyrosine kinase (MERTK) is expressed in a variety of malignancies, including glioblastoma multiforme (GBM)
27783662Our previous work demonstrated that inhibition of MERTK using RNA interference induced cell death and chemosensitivity in GBM cells, implicating MERTK as a potential therapeutic target
27783662METHODS: Correlations between expression of GAS6, a MERTK ligand, and prognosis were determined using data from the TCGA database
27783662CONCLUSIONS: The findings described here provide further evidence of oncogenic roles for MERTK in GBM, demonstrate the importance of kinase activity for MERTK tumorigenicity and validate UNC2025, a novel MERTK inhibitor, as a potential therapeutic agent for treatment of GBM
Entries Per Page
Displaying Page of