HCSGD entry for CDX2
1. General information
| Official gene symbol | CDX2 |
|---|---|
| Entrez ID | 1045 |
| Gene full name | caudal type homeobox 2 |
| Other gene symbols | CDX-3 CDX3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000794 | Condensed nuclear chromosome | IEA | cellular_component |
| GO:0000976 | Transcription regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0001568 | Blood vessel development | IEA | biological_process |
| GO:0001829 | Trophectodermal cell differentiation | IEA | biological_process |
| GO:0003690 | Double-stranded DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008333 | Endosome to lysosome transport | IEA | biological_process |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0017053 | Transcriptional repressor complex | IEA | cellular_component |
| GO:0035019 | Somatic stem cell maintenance | IEA | biological_process |
| GO:0045197 | Establishment or maintenance of epithelial cell apical/basal polarity | IEA | biological_process |
| GO:0045597 | Positive regulation of cell differentiation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0060711 | Labyrinthine layer development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5478070742 | 0.8502126135 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0905528164 |
| GSE13712_SHEAR | Down | -0.0019380146 |
| GSE13712_STATIC | Up | 0.1625507607 |
| GSE19018 | Up | 0.0511421541 |
| GSE19899_A1 | Down | -0.1047541725 |
| GSE19899_A2 | Up | 0.2287012695 |
| PubMed_21979375_A1 | Up | 0.1293492738 |
| PubMed_21979375_A2 | Down | -0.0246458021 |
| GSE35957 | Up | 0.0512890743 |
| GSE36640 | Down | -0.0113944048 |
| GSE54402 | Up | 0.0514461379 |
| GSE9593 | Up | 0.1273526443 |
| GSE43922 | Up | 0.0506265888 |
| GSE24585 | Up | 0.1407360660 |
| GSE37065 | Down | -0.0287297132 |
| GSE28863_A1 | Up | 0.0920382408 |
| GSE28863_A2 | Down | -0.1235723151 |
| GSE28863_A3 | Up | 0.3649014341 |
| GSE28863_A4 | Down | -0.1637750890 |
| GSE48662 | Up | 0.0116596528 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181c-5p | MIMAT0000258 | MIRT000235 | Luciferase reporter assay | Functional MTI | 19585654 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT000240 | Luciferase reporter assay | Functional MTI | 19585654 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT000245 | Luciferase reporter assay | Functional MTI | 19585654 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT005783 | Flow//Immunohistochemistry//Luciferase reporter assay//Western blot | Functional MTI | 21225631 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005784 | Luciferase reporter assay | Non-Functional MTI | 21225631 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018670 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-484 | MIMAT0002174 | MIRT042133 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-181b-5p | MIMAT0000257 | 1 | hsa-miR-181b | {Western blot} | {downregulation} | 19585654 | |
| hsa-miR-181a-5p | MIMAT0000256 | 1 | hsa-miR-181a | {Western blot} | {downregulation} | 19585654 | |
| hsa-miR-181c-5p | MIMAT0000258 | 1 | hsa-miR-181c | {Western blot} | {downregulation} | 19585654 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18845559 | Cdx2 is an intestine-specific transcription factor that is ectopically expressed in BE, but its role in this process is unclear |
| 18845559 | Retroviral-mediated Cdx2 expression in immortalized human esophageal keratinocytes [EPC-human telomerase reverse transcriptase (hTERT)] could transiently be established but not maintained and was associated with a reduction in cell proliferation |
| 18845559 | Cdx2 expression in the EPC-hTERT |
| 18845559 | Multiple Cdx2 target genes, markers of intestinal differentiation and markers of BE, were induced by this 5-AzaC treatment |
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