HCSGD entry for LYPLA1
1. General information
| Official gene symbol | LYPLA1 |
|---|---|
| Entrez ID | 10434 |
| Gene full name | lysophospholipase I |
| Other gene symbols | APT-1 LPL1 LYSOPLA hAPT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002084 | Protein depalmitoylation | IEA | biological_process |
| GO:0004622 | Lysophospholipase activity | TAS | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0006631 | Fatty acid metabolic process | IEA | biological_process |
| GO:0008474 | Palmitoyl-(protein) hydrolase activity | IMP TAS | molecular_function |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0042997 | Negative regulation of Golgi to plasma membrane protein transport | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046209 | Nitric oxide metabolic process | TAS | biological_process |
| GO:0050999 | Regulation of nitric-oxide synthase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0051646898 | 0.4480032636 | 0.1877621547 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4342349383 |
| GSE13712_SHEAR | Up | 0.2033689783 |
| GSE13712_STATIC | Up | 0.0912638721 |
| GSE19018 | Up | 0.3600674638 |
| GSE19899_A1 | Up | 2.2239721392 |
| GSE19899_A2 | Up | 1.2654365040 |
| PubMed_21979375_A1 | Up | 2.5919092118 |
| PubMed_21979375_A2 | Up | 1.3987978199 |
| GSE35957 | Down | -0.0489996903 |
| GSE36640 | Down | -0.4860234268 |
| GSE54402 | Up | 1.3025171203 |
| GSE9593 | Down | -0.5855243069 |
| GSE43922 | Up | 1.1564742322 |
| GSE24585 | Down | -0.5168822451 |
| GSE37065 | Down | -0.1534155516 |
| GSE28863_A1 | Down | -0.3525043798 |
| GSE28863_A2 | Up | 0.2442782502 |
| GSE28863_A3 | Down | -0.1633494914 |
| GSE28863_A4 | Down | -0.0928501230 |
| GSE48662 | Down | -0.5150242363 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045770 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047071 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
