HCSGD entry for TUBA1B

1. General information

Official gene symbolTUBA1B
Entrez ID10376
Gene full nametubulin, alpha 1b
Other gene symbolsK-ALPHA-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIEAbiological_process
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003924GTPase activityIEAmolecular_function
GO:0005198Structural molecule activityTASmolecular_function
GO:0005200Structural constituent of cytoskeletonIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005874MicrotubuleIDA IEA TAScellular_component
GO:0005881Cytoplasmic microtubuleIEAcellular_component
GO:0006457Protein foldingTASbiological_process
GO:0007017Microtubule-based processIEA TASbiological_process
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030705Cytoskeleton-dependent intracellular transportTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0051258Protein polymerizationIEAbiological_process
GO:0051301Cell divisionTASbiological_process
GO:0071353Cellular response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99302568670.02122241180.99999024730.2819763251

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0180317868
GSE13712_SHEARDown-0.0455376868
GSE13712_STATICDown-0.0923215422
GSE19018Up0.0219539056
GSE19899_A1Down-0.2839005479
GSE19899_A2Down-0.3519255595
PubMed_21979375_A1Down-0.3897682507
PubMed_21979375_A2Down-0.3538977136
GSE35957Down-0.6869928957
GSE36640Down-0.3688948923
GSE54402Up0.0283837323
GSE9593Down-0.2809366422
GSE43922Down-0.2204627532
GSE24585Down-0.0570232854
GSE37065Down-0.2267416792
GSE28863_A1Down-0.1347221993
GSE28863_A2Down-0.3710800744
GSE28863_A3Down-0.1479933015
GSE28863_A4Up0.0746891878
GSE48662Down-1.1016204834

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Epothilone DDB01873 EXPT01350
Epothilone BDB03010 EXPT01349
CYT997DB05147 -
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDEDB07574 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016595ProteomicsFunctional MTI (Weak)21512034
hsa-miR-1229-3pMIMAT0005584MIRT036296CLASHFunctional MTI (Weak)23622248
hsa-miR-760MIMAT0004957MIRT036718CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036931CLASHFunctional MTI (Weak)23622248
hsa-miR-877-5pMIMAT0004949MIRT037246CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037513CLASHFunctional MTI (Weak)23622248
hsa-miR-505-5pMIMAT0004776MIRT037972CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038384CLASHFunctional MTI (Weak)23622248
hsa-miR-140-3pMIMAT0004597MIRT038647CLASHFunctional MTI (Weak)23622248
hsa-miR-421MIMAT0003339MIRT039413CLASHFunctional MTI (Weak)23622248
hsa-miR-652-3pMIMAT0003322MIRT039463CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040370CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042042CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043044CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044555CLASHFunctional MTI (Weak)23622248
hsa-miR-182-5pMIMAT0000259MIRT047209CLASHFunctional MTI (Weak)23622248
hsa-miR-10b-5pMIMAT0000254MIRT047458CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048190CLASHFunctional MTI (Weak)23622248
hsa-miR-107MIMAT0000104MIRT048292CLASHFunctional MTI (Weak)23622248
hsa-miR-30a-5pMIMAT0000087MIRT049937CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051439CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052015CLASHFunctional MTI (Weak)23622248
hsa-miR-3934-5pMIMAT0018349MIRT052893CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24156782In the functional study, AT13387 inhibited cell migration with downregulation of a cell migration regulator, HDAC6, and increased the acetylation and stabilization of alpha-tubulin
14728717In fact, the protein level of alpha-tubulin was also drastically decreased in senescence-like arrested cells treated with higher concentrations of MNNG
7796463To shed light on the relationship between functions of the cytoskeleton and senescence or immortalization, we investigated the alterations in gene expression after immortalization and measured the amounts of mRNAs for talin, vinculin, alpha-actinin, tropomyosin 1 (TM1), vimentin, lamin A and C, and alpha-tubulin by slot blot and Northern blot analyses
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