HCSGD entry for CITED2

1. General information

Official gene symbolCITED2
Entrez ID10370
Gene full nameCbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Other gene symbolsASD8 MRG-1 MRG1 P35SRJ VSD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000790Nuclear chromatinISScellular_component
GO:0001102RNA polymerase II activating transcription factor bindingIEAmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIEAmolecular_function
GO:0001106RNA polymerase II transcription corepressor activityIDAmolecular_function
GO:0001570VasculogenesisIEAbiological_process
GO:0001666Response to hypoxiaIDA IMPbiological_process
GO:0001829Trophectodermal cell differentiationIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0001889Liver developmentISSbiological_process
GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0002089Lens morphogenesis in camera-type eyeIEAbiological_process
GO:0002244Hematopoietic progenitor cell differentiationIEAbiological_process
GO:0003151Outflow tract morphogenesisISSbiological_process
GO:0003156Regulation of organ formationISSbiological_process
GO:0003197Endocardial cushion developmentIEAbiological_process
GO:0003682Chromatin bindingISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0003714Transcription corepressor activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IMPcellular_component
GO:0005737CytoplasmIMPcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0007368Determination of left/right symmetryISSbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0007422Peripheral nervous system developmentIEAbiological_process
GO:0007507Heart developmentIMP ISSbiological_process
GO:0007530Sex determinationISSbiological_process
GO:0007569Cell agingIEAbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010629Negative regulation of gene expressionIDAbiological_process
GO:0021602Cranial nerve morphogenesisIEAbiological_process
GO:0022409Positive regulation of cell-cell adhesionISSbiological_process
GO:0030336Negative regulation of cell migrationIMPbiological_process
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayISSbiological_process
GO:0030851Granulocyte differentiationIEAbiological_process
GO:0034405Response to fluid shear stressIMPbiological_process
GO:0035035Histone acetyltransferase bindingIDAmolecular_function
GO:0035360Positive regulation of peroxisome proliferator activated receptor signaling pathwayIDAbiological_process
GO:0035802Adrenal cortex formationISSbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0043627Response to estrogenIDAbiological_process
GO:0045787Positive regulation of cell cycleISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0046332SMAD bindingIEAmolecular_function
GO:0046697DecidualizationIEAbiological_process
GO:0048536Spleen developmentISSbiological_process
GO:0048538Thymus developmentIEAbiological_process
GO:0048596Embryonic camera-type eye morphogenesisIEAbiological_process
GO:0048821Erythrocyte developmentIEAbiological_process
GO:0050693LBD domain bindingIPImolecular_function
GO:0060136Embryonic process involved in female pregnancyIEAbiological_process
GO:0060349Bone morphogenesisIEAbiological_process
GO:0060412Ventricular septum morphogenesisISSbiological_process
GO:0060971Embryonic heart tube left/right pattern formationISSbiological_process
GO:0061156Pulmonary artery morphogenesisIEAbiological_process
GO:0061308Cardiac neural crest cell development involved in heart developmentIEAbiological_process
GO:0061428Negative regulation of transcription from RNA polymerase II promoter in response to hypoxiaIDAbiological_process
GO:0070986Left/right axis specificationISSbiological_process
GO:1900164Nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetryISSbiological_process
GO:2000020Positive regulation of male gonad developmentISSbiological_process
GO:2001141Regulation of RNA biosynthetic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09803975530.06247822650.65372348020.4712004011

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7557622431
GSE13712_SHEARUp0.6673953088
GSE13712_STATICUp0.4868890060
GSE19018Up0.9552761144
GSE19899_A1Down-0.6613983705
GSE19899_A2Up0.8164283379
PubMed_21979375_A1Up0.9368474293
PubMed_21979375_A2Up0.0858581332
GSE35957Up0.4743338938
GSE36640Up0.4733121944
GSE54402Down-0.7119099324
GSE9593Up0.3215997482
GSE43922Down-0.3595792279
GSE24585Down-0.8673301014
GSE37065Down-0.1454127250
GSE28863_A1Down-0.0671276652
GSE28863_A2Up0.0567477230
GSE28863_A3Down-0.3188934146
GSE28863_A4Down-0.1900209902
GSE48662Down-0.1505331396

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-590-3pMIMAT0004801MIRT016167SequencingFunctional MTI (Weak)20371350
hsa-miR-335-5pMIMAT0000765MIRT017586MicroarrayFunctional MTI (Weak)18185580
hsa-miR-103a-3pMIMAT0000101MIRT027052SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20569237Cited2, a multi-stimuli responsive transactivator involved in cell growth and senescence, is also downregulated in aged TSPCs while CD44, a matrix assembling and organizing protein implicated in tendon healing, is upregulated, suggesting that these genes participate in the control of TSPC function
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