HCSGD entry for KLF2
1. General information
| Official gene symbol | KLF2 |
|---|---|
| Entrez ID | 10365 |
| Gene full name | Kruppel-like factor 2 (lung) |
| Other gene symbols | LKLF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000902 | Cell morphogenesis | IEA | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0032715 | Negative regulation of interleukin-6 production | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0036003 | Positive regulation of transcription from RNA polymerase II promoter in response to stress | IMP | biological_process |
| GO:0043249 | Erythrocyte maturation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IGI | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051247 | Positive regulation of protein metabolic process | IGI | biological_process |
| GO:0060509 | Type I pneumocyte differentiation | IEA | biological_process |
| GO:0070301 | Cellular response to hydrogen peroxide | IEA | biological_process |
| GO:0071347 | Cellular response to interleukin-1 | IEA | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IEA | biological_process |
| GO:0071409 | Cellular response to cycloheximide | IEA | biological_process |
| GO:0071499 | Cellular response to laminar fluid shear stress | IMP | biological_process |
| GO:1901653 | Cellular response to peptide | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9008879906 | 0.0655820865 | 0.9999902473 | 0.4835255182 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5153225956 |
| GSE13712_SHEAR | Down | -0.1086335105 |
| GSE13712_STATIC | Up | 0.0400232474 |
| GSE19018 | Down | -0.0114351759 |
| GSE19899_A1 | Down | -0.3083588918 |
| GSE19899_A2 | Down | -0.1708445389 |
| PubMed_21979375_A1 | Down | -0.8668856895 |
| PubMed_21979375_A2 | Down | -0.4876477139 |
| GSE35957 | Down | -0.2413409359 |
| GSE36640 | Down | -0.1973073311 |
| GSE54402 | Up | 0.0048574644 |
| GSE9593 | Down | -0.0381296402 |
| GSE43922 | Up | 0.0464103680 |
| GSE24585 | Up | 0.0174648585 |
| GSE37065 | Down | -0.2576943132 |
| GSE28863_A1 | Up | 0.0206852796 |
| GSE28863_A2 | Down | -0.2739861770 |
| GSE28863_A3 | Up | 0.5772215617 |
| GSE28863_A4 | Down | -0.0868483555 |
| GSE48662 | Down | -0.0090911097 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT006372 | Luciferase reporter assay | Functional MTI | 21768538 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023028 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26443543 | Similarly, two stilbenes also stimulated LKB1, AMPKalpha, extracellular-signal related kinase 5 (ERK5) phosphorylation, and histone acetylase 5 (HDAC5) and Kruppel-like factor 2 (KLF2) expression |
| 26443543 | Furthermore, using a chromatin immunoprecipitation-PCR detection method, we found that resveratrol and pterostilbene promoted KLF2 binding to CACCC sites of the human MnSOD promoter |
| 25655189 | We further revealed AKT signaling as a potential miR-143 target, and an induction of miR-143 expression by MEF2A via KLF2 |
| 24788960 | Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Kruppel-like factor 4 |
| 24788960 | Kruppel-like factor 4 (KLF4) is a zinc-finger-containing transcription factor with tumor suppressor activity in various cancer types |
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