HCSGD entry for CDKN3
1. General information
| Official gene symbol | CDKN3 |
|---|---|
| Entrez ID | 1033 |
| Gene full name | cyclin-dependent kinase inhibitor 3 |
| Other gene symbols | CDI1 CIP2 KAP KAP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0004722 | Protein serine/threonine phosphatase activity | IDA | molecular_function |
| GO:0004725 | Protein tyrosine phosphatase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0007050 | Cell cycle arrest | IDA | biological_process |
| GO:0008138 | Protein tyrosine/serine/threonine phosphatase activity | TAS | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9478963033 | 0.0000059800 | 0.9999902473 | 0.0069833333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.4027904882 |
| GSE13712_SHEAR | Down | -1.5784562070 |
| GSE13712_STATIC | Down | -1.4730207988 |
| GSE19018 | Up | 0.2839896492 |
| GSE19899_A1 | Down | -2.4772820482 |
| GSE19899_A2 | Down | -5.6745823515 |
| PubMed_21979375_A1 | Down | -4.8686546808 |
| PubMed_21979375_A2 | Down | -7.3964656709 |
| GSE35957 | Down | -4.9028496757 |
| GSE36640 | Down | -5.8482707636 |
| GSE54402 | Down | -1.5078660836 |
| GSE9593 | Down | -2.3494016506 |
| GSE43922 | Down | -3.5031134895 |
| GSE24585 | Up | 0.1868509068 |
| GSE37065 | Down | -0.7550865321 |
| GSE28863_A1 | Up | 0.0799149980 |
| GSE28863_A2 | Up | 0.6412035496 |
| GSE28863_A3 | Down | -0.2394973404 |
| GSE28863_A4 | Up | 0.3263880319 |
| GSE48662 | Down | -2.0205933179 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | MIRT005705 | Western blot | Non-Functional MTI | 19944095 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024518 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026751 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049159 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8706801 | Fourteen genes, including 3 cyclin-dependent kinase (CDK) inhibitors (p16INK4, p21SDI/CIP/WAF and p27KIP), 5 cyclins, 4 CDKs, Cdi-1, and PCNA were tested in four primary fibroblast strains |
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