HCSGD entry for AKR1A1
1. General information
| Official gene symbol | AKR1A1 |
|---|---|
| Entrez ID | 10327 |
| Gene full name | aldo-keto reductase family 1, member A1 (aldehyde reductase) |
| Other gene symbols | ALDR1 ALR ARM DD3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004032 | Alditol:NADP+ 1-oxidoreductase activity | TAS | molecular_function |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006081 | Cellular aldehyde metabolic process | TAS | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0019853 | L-ascorbic acid biosynthetic process | IEA | biological_process |
| GO:0042840 | D-glucuronate catabolic process | IEA | biological_process |
| GO:0046185 | Aldehyde catabolic process | IEA | biological_process |
| GO:0047939 | L-glucuronate reductase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4440932943 | 0.0834071388 | 0.9999902473 | 0.5481546317 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.2457732768 |
| GSE13712_SHEAR | Down | -0.9737734584 |
| GSE13712_STATIC | Down | -0.6091402176 |
| GSE19018 | Up | 0.3696692021 |
| GSE19899_A1 | Up | 0.1552416040 |
| GSE19899_A2 | Up | 0.0109338809 |
| PubMed_21979375_A1 | Up | 0.2972773274 |
| PubMed_21979375_A2 | Down | -0.1911040463 |
| GSE35957 | Down | -0.5103780448 |
| GSE36640 | Down | -0.1054534488 |
| GSE54402 | Up | 0.1604275858 |
| GSE9593 | Up | 0.2717710345 |
| GSE43922 | Down | -0.0199776454 |
| GSE24585 | Down | -0.0657179627 |
| GSE37065 | Down | -0.1851506053 |
| GSE28863_A1 | Down | -0.5525488848 |
| GSE28863_A2 | Up | 0.1340216468 |
| GSE28863_A3 | Down | -0.8150581896 |
| GSE28863_A4 | Down | -0.0147247739 |
| GSE48662 | Up | 0.1237961485 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tolrestat | DB02383 | EXPT03082 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025351 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032282 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045288 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21307604 | The SB system containing the telomerase gene controlled by two chimeric transthyretin (TTR) gene promoters/enhancers, the human alcohol dehydrogenase gene promoter (ADHp), and the SV40 viral enhancer (SV40VE) was constructed in order to activate hepatocyte cell growth |
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