HCSGD entry for CDKN2C
1. General information
| Official gene symbol | CDKN2C |
|---|---|
| Entrez ID | 1031 |
| Gene full name | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
| Other gene symbols | INK4C p18 p18-INK4C |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | IDA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004861 | Cyclin-dependent protein serine/threonine kinase inhibitor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IDA | biological_process |
| GO:0007050 | Cell cycle arrest | IDA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0030308 | Negative regulation of cell growth | IDA | biological_process |
| GO:0042326 | Negative regulation of phosphorylation | IDA | biological_process |
| GO:0043086 | Negative regulation of catalytic activity | IDA | biological_process |
| GO:0048709 | Oligodendrocyte differentiation | IEA | biological_process |
| GO:0071901 | Negative regulation of protein serine/threonine kinase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9975065499 | 0.0000528741 | 0.9999902473 | 0.0118779661 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0894602962 |
| GSE13712_SHEAR | Down | -1.5431740742 |
| GSE13712_STATIC | Down | -1.4375300633 |
| GSE19018 | Down | -0.0079889917 |
| GSE19899_A1 | Down | -1.3362046766 |
| GSE19899_A2 | Down | -3.3226651426 |
| PubMed_21979375_A1 | Down | -1.5010976104 |
| PubMed_21979375_A2 | Down | -4.5158534897 |
| GSE35957 | Down | -2.3120923891 |
| GSE36640 | Down | -3.4892766843 |
| GSE54402 | Down | -0.8652892242 |
| GSE9593 | Down | -1.3416836523 |
| GSE43922 | Down | -0.1855743861 |
| GSE24585 | Down | -0.0763226579 |
| GSE37065 | Down | -0.2467531991 |
| GSE28863_A1 | Up | 0.1844127697 |
| GSE28863_A2 | Up | 0.2201459256 |
| GSE28863_A3 | Down | -0.6357614936 |
| GSE28863_A4 | Up | 0.1523172781 |
| GSE48662 | Down | -0.8872569542 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025585 | Reporter assay;qRT-PCR | Functional MTI | 21128241 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22548705 | In the absence of the Cdk4-inhibitor p18Ink4c, cell cycle exit was delayed but most cells eventually showed a senescent phenotype |
| 22548705 | We found that the p53 pathway was intact in tumors arising in a p18Ink4c-/- background, indicating that the two genes represent distinct tumor suppressor pathways |
| 22548705 | Upon tumor progression, both p18Ink4c-/- and p53-/- tumors showed increased Cdk2 expression |
| 16288006 | Interestingly, we also found that, in the absence of p16INK4a, reexpression of hSNF5 also increased protein levels of a second cyclin-dependent kinase (CDK) inhibitor, p18INK4c |
| 16150936 | Of interest, the induction of HSC senescence was associated with a prolonged elevation of p21(Cip1/Waf1), p19(Arf), and p16(Ink4a) mRNA expression, while the expression of p27(Kip1) and p18(Ink4c) mRNA was not increased following TBI |
| 10851091 | Assembly and activity of the proto-oncogenic cyclin D/CDK4(6) complexes, the major driving force of G1 phase progression, is negatively regulated by a family of INK4 CDK inhibitors p16INK4a, p15INK4b, p18INK4c, and p19INK4d |
| 9244355 | Both p18INK4c and p19INK4d were widely expressed during mouse embryogenesis, but p16INK4a and p15INK4b were not readily detected prenatally |
| 9244355 | Although p15INK4b, p18INK4c and p19INK4d were demonstrated in many tissues by 4 weeks after birth, p16INK4a protein expression was restricted to the lung and spleen of older mice, with increased, more widespread mRNA expression during aging |
| 9244355 | The levels of p16INK4a and p18INK4c, but not p15INK4b or p19INK4d, further increased as MEFs approached senescence |
| 9244355 | Whereas p18INK4c and p19INK4d may regulate pre- and postnatal development, p16INK4a more likely plays a checkpoint function during cell senescence that underscores its selective role as a tumor suppressor |
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