HCSGD entry for MARCH6
1. General information
| Official gene symbol | MARCH6 |
|---|---|
| Entrez ID | 10299 |
| Gene full name | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase |
| Other gene symbols | DOA10 MARCH-VI RNF176 TEB4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004842 | Ubiquitin-protein ligase activity | IDA IMP | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030176 | Integral component of endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0031624 | Ubiquitin conjugating enzyme binding | IPI | molecular_function |
| GO:0070936 | Protein K48-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2793200562 | 0.6743319327 | 0.9762293454 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1607502407 |
| GSE13712_SHEAR | Up | 0.0908670583 |
| GSE13712_STATIC | Down | -0.0876907424 |
| GSE19018 | Up | 0.4063106717 |
| GSE19899_A1 | Down | -0.0166832517 |
| GSE19899_A2 | Up | 0.0552113645 |
| PubMed_21979375_A1 | Down | -0.1104673187 |
| PubMed_21979375_A2 | Up | 0.0104394135 |
| GSE35957 | Up | 0.2911638055 |
| GSE36640 | Up | 0.1179844754 |
| GSE54402 | Down | -0.1239448892 |
| GSE9593 | Down | -0.0561222426 |
| GSE43922 | Up | 0.0056224157 |
| GSE24585 | Up | 0.6547757613 |
| GSE37065 | Up | 0.0839095967 |
| GSE28863_A1 | Up | 0.3896738233 |
| GSE28863_A2 | Up | 0.2297090666 |
| GSE28863_A3 | Down | -0.2424054780 |
| GSE28863_A4 | Down | -0.4009404707 |
| GSE48662 | Up | 0.1799078489 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-25-3p | MIMAT0000081 | MIRT050267 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051174 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052052 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
