HCSGD entry for CDKN1C
1. General information
| Official gene symbol | CDKN1C |
|---|---|
| Entrez ID | 1028 |
| Gene full name | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| Other gene symbols | BWCR BWS KIP2 WBS p57 p57Kip2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0000080 | Mitotic G1 phase | TAS | biological_process |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001890 | Placenta development | IEA | biological_process |
| GO:0004861 | Cyclin-dependent protein serine/threonine kinase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | TAS | biological_process |
| GO:0007050 | Cell cycle arrest | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0030511 | Positive regulation of transforming growth factor beta receptor signaling pathway | IMP | biological_process |
| GO:0033673 | Negative regulation of kinase activity | IDA | biological_process |
| GO:0042326 | Negative regulation of phosphorylation | IDA | biological_process |
| GO:0042551 | Neuron maturation | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IGI | biological_process |
| GO:0050680 | Negative regulation of epithelial cell proliferation | IMP | biological_process |
| GO:0071901 | Negative regulation of protein serine/threonine kinase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8542157517 | 0.0246473500 | 0.9999902473 | 0.3027265049 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2273343704 |
| GSE13712_SHEAR | Down | -0.9856684856 |
| GSE13712_STATIC | Down | -0.8908110672 |
| GSE19018 | Up | 0.0482006738 |
| GSE19899_A1 | Down | -0.3537502232 |
| GSE19899_A2 | Down | -0.9263964619 |
| PubMed_21979375_A1 | Down | -0.5783509512 |
| PubMed_21979375_A2 | Down | -0.6350379632 |
| GSE35957 | Down | -0.1712885303 |
| GSE36640 | Down | -0.3846310289 |
| GSE54402 | Down | -0.4453564822 |
| GSE9593 | Down | -0.4564501987 |
| GSE43922 | Up | 0.0639893708 |
| GSE24585 | Up | 0.1564185956 |
| GSE37065 | Down | -0.1103839788 |
| GSE28863_A1 | Up | 0.1036810056 |
| GSE28863_A2 | Down | -0.0253102859 |
| GSE28863_A3 | Up | 0.5678566130 |
| GSE28863_A4 | Up | 0.0778424213 |
| GSE48662 | Up | 0.0995238606 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-222-3p | MIMAT0000279 | MIRT000719 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19153141 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000719 | Luciferase reporter assay//Western blot | Functional MTI | 19589872 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000719 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 18413744 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000719 | qRT-PCR | Functional MTI (Weak) | 23447020 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT002272 | Reporter assay//Luciferase reporter assay//qRT-PCR//Western blot//Northern blot | Functional MTI | 18521080 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT002272 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19153141 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT002272 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21278784 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT002272 | Reporter assay;Microarray | Functional MTI | 20018759 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT002272 | Reporter assay | Functional MTI | 18413744 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT004293 | Luciferase reporter assay//Western blot | Functional MTI | 19544458 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT004317 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19153141 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018103 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | {Western blot}{Western blot} | {overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides} | 18413744 | |
| hsa-miR-222-3p | MIMAT0000279 | 1 | hsa-miR-222 | {Western blot}{Western blot} | {overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides} | 18413744 | |
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | 18521080 | |||
| hsa-miR-222-3p | MIMAT0000279 | 1 | hsa-miR-222 | {Western blot} | {downregulation by anti-miRNA oligonucleotide} | 19589872 | |
| hsa-miR-92b-3p | MIMAT0003218 | NA | hsa-miR-92b | {Western blot} | {downregulation by anti-miRNA oligonucleotide} | 19544458 | |
| hsa-miR-221-3p | MIMAT0000278 | NA | hsa-miR-221 | {Western blot} | {overexpression by miRNA precursor transfection} | 21226887 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
