HCSGD entry for CDKN1B
1. General information
| Official gene symbol | CDKN1B |
|---|---|
| Entrez ID | 1027 |
| Gene full name | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| Other gene symbols | CDKN4 KIP1 MEN1B MEN4 P27KIP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | TAS | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0004861 | Cyclin-dependent protein serine/threonine kinase inhibitor activity | IEA | molecular_function |
| GO:0005072 | Transforming growth factor beta receptor, cytoplasmic mediator activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005768 | Endosome | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006813 | Potassium ion transport | IEA | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | biological_process |
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | TAS | biological_process |
| GO:0007050 | Cell cycle arrest | IEA IMP | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007605 | Sensory perception of sound | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA IMP | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008656 | Cysteine-type endopeptidase activator activity involved in apoptotic process | IDA | molecular_function |
| GO:0009749 | Response to glucose | IEA | biological_process |
| GO:0010942 | Positive regulation of cell death | IDA | biological_process |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0030308 | Negative regulation of cell growth | IDA | biological_process |
| GO:0030544 | Hsp70 protein binding | IEA | molecular_function |
| GO:0031116 | Positive regulation of microtubule polymerization | IEA | biological_process |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0033673 | Negative regulation of kinase activity | IDA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0042326 | Negative regulation of phosphorylation | IDA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0043200 | Response to amino acid | IEA | biological_process |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0043434 | Response to peptide hormone | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045732 | Positive regulation of protein catabolic process | IDA | biological_process |
| GO:0045736 | Negative regulation of cyclin-dependent protein serine/threonine kinase activity | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045930 | Negative regulation of mitotic cell cycle | IDA | biological_process |
| GO:0046686 | Response to cadmium ion | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0048102 | Autophagic cell death | IDA | biological_process |
| GO:0048839 | Inner ear development | IEA | biological_process |
| GO:0051087 | Chaperone binding | IEA | molecular_function |
| GO:0051271 | Negative regulation of cellular component movement | IEA | biological_process |
| GO:0060770 | Negative regulation of epithelial cell proliferation involved in prostate gland development | IEA | biological_process |
| GO:0071236 | Cellular response to antibiotic | IEA | biological_process |
| GO:0071285 | Cellular response to lithium ion | IDA | biological_process |
| GO:0071407 | Cellular response to organic cyclic compound | IEA | biological_process |
| GO:0071850 | Mitotic cell cycle arrest | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2073848828 | 0.0035734813 | 0.8781560881 | 0.1213646452 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8888449570 |
| GSE13712_SHEAR | Down | -0.0527483017 |
| GSE13712_STATIC | Down | -0.8315434978 |
| GSE19018 | Up | 0.7172047424 |
| GSE19899_A1 | Down | -1.5346725895 |
| GSE19899_A2 | Down | -1.6475709556 |
| PubMed_21979375_A1 | Down | -2.2481548108 |
| PubMed_21979375_A2 | Down | -2.1840874945 |
| GSE35957 | Down | -0.3473122318 |
| GSE36640 | Down | -1.2083362070 |
| GSE54402 | Down | -0.4815823246 |
| GSE9593 | Down | -0.6602821889 |
| GSE43922 | Down | -1.0257711716 |
| GSE24585 | Up | 0.9412086383 |
| GSE37065 | Down | -0.2208814306 |
| GSE28863_A1 | Up | 0.3109577512 |
| GSE28863_A2 | Up | 0.5462783717 |
| GSE28863_A3 | Up | 0.1729164731 |
| GSE28863_A4 | Up | 0.2313290931 |
| GSE48662 | Down | -0.0043106819 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Luciferase reporter assay//Western blot//Western blot;Other//Northern blot | Functional MTI | 17569667 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19153141 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Western blot//Northern blot | Functional MTI | 19107213 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Luciferase reporter assay//Western blot | Functional MTI | 19859555 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18417445 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Luciferase reporter assay | Functional MTI | 19150885 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Luciferase reporter assay | Functional MTI | 18983236 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Luciferase reporter assay | Functional MTI | 18246122 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | immunohistochemistry//Microarray//qRT-PCR | Functional MTI (Weak) | 20012062 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Northern blot//qRT-PCR//Western blot | Functional MTI | 20018759 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Immunohistochemistry//In situ hybridization//Luciferase reporter assay//Northern blot//Western blot//Reporter assay;Western blot | Functional MTI | 19424584 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Western blot//Reporter assay | Functional MTI | 17721077 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Luciferase reporter assay | Functional MTI | 17627278 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | qRT-PCR//Western blot | Functional MTI | 18708351 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | qRT-PCR | Functional MTI (Weak) | 23447020 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Reporter assay | Functional MTI | 17914108 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT000131 | Reporter assay | Functional MTI | 18413744 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay//Western blot//Northern blot;Western blot | Functional MTI | 17569667 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19088079 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay//Western blot | Functional MTI | 18155131 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19153141 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Western blot//Northern blot | Functional MTI | 19107213 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay//Western blot | Functional MTI | 19859555 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay | Functional MTI | 18246122 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay | Functional MTI | 19150885 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay | Functional MTI | 18521080 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay | Functional MTI | 18834855 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay | Functional MTI | 18983236 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay | Functional MTI | 19749093 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18417445 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | immunohistochemistry//Microarray//qRT-PCR | Functional MTI (Weak) | 20012062 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Northern blot//qRT-PCR//Western blot | Functional MTI | 20018759 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Immunohistochemistry//In situ hybridization//Luciferase reporter assay//Northern blot//Western blot//Reporter assay;Western blot | Functional MTI | 19424584 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 17721077 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Luciferase reporter assay//Western blot | Functional MTI | 17627278 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | qRT-PCR//Western blot | Functional MTI | 18708351 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Reporter assay | Functional MTI | 17914108 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT000137 | Reporter assay | Functional MTI | 18413744 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT004554 | Luciferase reporter assay//Western blot//Reporter assay;Western blot;qRT-PCR | Functional MTI | 19273599 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT004554 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT005063 | Luciferase reporter assay | Non-Functional MTI | 17627278 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT005063 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20816961 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT005063 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT005063 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT005063 | Flow//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23553486 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT005064 | Luciferase reporter assay | Non-Functional MTI | 17627278 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT005065 | Luciferase reporter assay | Non-Functional MTI | 17627278 |
| hsa-miR-190a-5p | MIMAT0000458 | MIRT005066 | Luciferase reporter assay | Non-Functional MTI | 17627278 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT005067 | Luciferase reporter assay | Non-Functional MTI | 17627278 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027709 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052676 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | NA | hsa-miR-221 | 18155131 | |||
| hsa-miR-221-3p | MIMAT0000278 | NA | hsa-miR-221 | {Western blot} | {underexpression by anti-miRNA oligonucleotides} | 17721077 | |
| hsa-miR-222-3p | MIMAT0000279 | NA | hsa-miR-222 | {Western blot} | {underexpression by anti-miRNA oligonucleotides} | 17721077 | |
| hsa-miR-221-3p | MIMAT0000278 | 2 | hsa-miR-221 | {Western blot}{Western blot} | {overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides} | 18413744 | |
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | {Western blot}{Western blot} | {overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides} | 18413744 | |
| hsa-miR-222-3p | MIMAT0000279 | 1 | hsa-miR-222 | {Western blot}{Western blot} | {overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides} | 18413744 | |
| hsa-miR-222-3p | MIMAT0000279 | 2 | hsa-miR-222 | {Western blot}{Western blot} | {overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides} | 18413744 | |
| hsa-miR-221-3p | MIMAT0000278 | NA | hsa-miR-221 | {Western blot}{Western blot} | {overexpression}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 18417445 | |
| hsa-miR-222-3p | MIMAT0000279 | NA | hsa-miR-222 | {Western blot}{Western blot} | {overexpression}{underexpression by 2'-O-Me antisense miRNA oligonucleotides} | 18417445 | |
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides} | 17569667 | |
| hsa-miR-221-3p | MIMAT0000278 | 3 | hsa-miR-221 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides} | 17569667 | |
| hsa-miR-221-3p | MIMAT0000278 | 2 | hsa-miR-221 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides} | 17569667 | |
| hsa-miR-222-3p | MIMAT0000279 | 3 | hsa-miR-222 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides} | 17569667 | |
| hsa-miR-222-3p | MIMAT0000279 | 2 | hsa-miR-222 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides} | 17569667 | |
| hsa-miR-222-3p | MIMAT0000279 | 1 | hsa-miR-222 | {Western blot}{Western blot} | {overexpression by miRNA precursor transfection}{underexpression by LNA antisense miRNA oligonucleotides} | 17569667 | |
| hsa-miR-221-3p | MIMAT0000278 | NA | hsa-miR-221 | {Western blot}{Western blot} | {overexpression by mature miRNA transfection}{underexpression by anti-miRNA oligonucleotides} | 17627278 | |
| hsa-miR-221-3p | MIMAT0000278 | NA | hsa-miR-221 | {Western blot} | {overexpression} | 18708351 | |
| hsa-miR-222-3p | MIMAT0000279 | NA | hsa-miR-222 | {Western blot} | {overexpression} | 18708351 | |
| hsa-miR-222-3p | MIMAT0000279 | NA | hsa-miR-222 | {Western blot} | {downregulation by LNA antisense miRNA oligonucleotide} | 19107216 | |
| hsa-miR-221-3p | MIMAT0000278 | NA | hsa-miR-221 | {Western blot} | {downregulation by LNA antisense miRNA oligonucleotide} | 19107213 | |
| hsa-miR-181a-5p | MIMAT0000256 | NA | hsa-miR-181a | {Western blot} | {overexpression by miRNA precursor transfection} | 19273599 | |
| hsa-miR-296-5p | MIMAT0000690 | NA | hsa-miR-296-5p | {Western blot} | {downregulation} | 20485139 | |
| hsa-miR-148a-3p | MIMAT0000243 | 1 | hsa-miR-148a | {Western blot} | {overexpression by miRNA precursor transfection} | 21552422 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24149709 | Cdkn1b overexpression in adult mice alters the balance between genome and tissue ageing |
| 24149709 | Here we increase levels of the cyclin-dependent kinase inhibitor Cdkn1b (p27kip1) in adult mice through doxycycline-inducible expression and show this results in reduced cell proliferation in multiple tissues |
| 21286718 | Irinotecan increases phosphorylation of EGFR, MAPK, and AKT and decreases the expression of P27(Kip1), which could be all abrogated by its combination with cetuximab |
| 17483349 | This inhibitory activity was associated with a selective up-regulation of the cyclin-dependent kinase inhibitor P27(KIP1) and induction of cellular senescence |
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