HCSGD entry for CDK7

1. General information

Official gene symbolCDK7
Entrez ID1022
Gene full namecyclin-dependent kinase 7
Other gene symbolsCAK1 CDKN7 HCAK MO15 STK1 p39MO15
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000079Regulation of cyclin-dependent protein serine/threonine kinase activityTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000718Nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0003713Transcription coactivator activityNASmolecular_function
GO:0004672Protein kinase activityIEA TASmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004693Cyclin-dependent protein serine/threonine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005675Holo TFIIH complexIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairTASbiological_process
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterTASbiological_process
GO:0006362Transcription elongation from RNA polymerase I promoterTASbiological_process
GO:0006363Termination of RNA polymerase I transcriptionTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006368Transcription elongation from RNA polymerase II promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIDAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0030521Androgen receptor signaling pathwayNASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050434Positive regulation of viral transcriptionTASbiological_process
GO:0050681Androgen receptor bindingNASmolecular_function
GO:0051301Cell divisionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71844657120.13234943580.99999024730.7009315631

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0475974031
GSE13712_SHEARUp0.3571578646
GSE13712_STATICUp0.3230316356
GSE19018Down-1.0945156396
GSE19899_A1Down-0.0209026904
GSE19899_A2Down-0.1456444332
PubMed_21979375_A1Up0.1340675454
PubMed_21979375_A2Down-0.3049300335
GSE35957Down-0.0977856305
GSE36640Up0.5787749013
GSE54402Up0.0101286016
GSE9593Up0.3224554768
GSE43922Down-0.0225193539
GSE24585Down-0.0539868309
GSE37065Down-0.0093804390
GSE28863_A1Down-0.2119905729
GSE28863_A2Down-0.1871650665
GSE28863_A3Down-0.2330158223
GSE28863_A4Down-0.0440873837
GSE48662Down-0.2322824888

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhosphonothreonineDB02482 EXPT03092
FlavopiridolDB03496 EXPT00998

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT027787MicroarrayFunctional MTI (Weak)19088304
hsa-miR-423-3pMIMAT0001340MIRT042517CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.